Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …

THE MAMMALIAN IMMUNE SYSTEM can be broadly divided into two main arms: innate and
adaptive immunity. As its name implies, the cells and receptors of the innate immune system …

Single-cell genomics studies have decoded the immune cell composition of several human
prenatal organs but were limited in describing the developing immune system as a …

Clinical successes demonstrated by chimeric antigen receptor T-cell immunotherapy have
facilitated further development of T-cell immunotherapy against wide variety of diseases …

Abstract Forkhead box P3 (FOXP3)+ regulatory T (TReg) cells are potent mediators of
dominant self tolerance in the periphery. But confusion as to the identity, stability and …

Sézary syndrome is a rare leukemic form of cutaneous T cell lymphoma characterized by
generalized redness, scaling, itching and increased numbers of circulating atypical T …

Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of orphan neoplasms.
Despite the introduction of anthracycline-based chemotherapy protocols, with or without …

Immune cell differentiation is critical for adequate tissue-specific immune responses to
occur. Here, we studied differentiation of human uterine natural killer cells (uNK cells) …

T cells, in particular CD4+ T cells, have been implicated in mediating many aspects of
autoimmune inflammation. However, current evidence suggests that the role played by …

The lymphocytes, T, B, and NK cells, and a proportion of dendritic cells (DCs) have a
common developmental origin. Lymphocytes develop from hematopoietic stem cells via …