There is an increasing amount of knowledge on the functional properties of regulatory T
cells (Treg) in the adult immune system, but data on the generation and function of these …

Human mucosal-associated invariant T (MAIT) cells express the semi-invariant T-cell
receptor (TCR) Vα7. 2 and are restricted by the major histocompatibility complex-Ib molecule …

T cells show tremendous efficacy as cellular therapeutics. However, obtaining primary T
cells from human donors is expensive and variable. Pluripotent stem cells (PSCs) have the …

CD4+ recent thymic emigrants (RTEs) comprise a clinically and immunologically important T
cell population that indicates thymic output and that is essential for maintaining a diverse αβ …

In cancer, non-synonymous DNA base changes alter protein sequence and produce
neoantigens that are detected by the immune system. For immune detection, neoantigens …

T-cell development follows a defined set of stage-specific differentiation steps. However,
molecular and cellular events occurring at early stages of human T-cell development remain …

The viral accessory protein Vpx, expressed by certain simian and human immunodeficiency
viruses (SIVs and HIVs), is thought to improve viral infectivity of myeloid cells. We infected 35 …

Inborn errors of thymic stromal cell development and function lead to impaired T-cell
development resulting in a susceptibility to opportunistic infections and autoimmunity. In …

Polysialic acid (polySia) is a highly regulated polymer of sialic acid (Sia) with such potent
biophysical characteristics that when expressed drastically influences the interaction …

Radiation exposure causes acute damage to hematopoietic and immune cells. To date,
there are no radioprotectors available to mitigate hematopoietic injury after radiation …