We investigated the molecular mechanism underlying a severe combined immunodeficiency
characterized by the selective and complete absence of T cells. The condition was found in …

Little is known about the ontogeny of naturally occurring CD4+ CD25+
regulatory/suppressor T cells that play a major role in maintaining self-tolerance in mice and …

Recent deep sequencing studies on T-cell receptor (TCR) repertoire have provided robust
data to characterize diversity of T-cell immune responsiveness to a wide variety of peptide …

Aberrant expression of transcription factor oncogenes such as HOX11, HOX11L2,
TAL1/SCL, LYL1, LMO1, and LMO2 can be detected in lymphoblasts from up to 80% of …

Here, we identify fetal bone marrow (BM)-derived CD34 hi CD45RA hi CD7+ hematopoietic
progenitors as thymus-colonizing cells. This population, virtually absent from the fetal liver …

Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T
cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs …

Glucocorticoids (GCs) are a central component of therapy for patients with T cell acute
lymphoblastic leukemia (T-ALL), and although resistance to GCs is a strong negative …

The transcription factor FoxN1 is essential for differentiation of thymic epithelial cell (TEC)
progenitors during thymic organogenesis. However, limited information is available on the …

T lymphocyte activation is associated with activation of diverse AGC serine kinases (named
after family members protein kinase A, protein kinase G and protein kinase C). It has been …

The adaptive immune response relies on the ability of lymphocytes to undergo periodic
massive expansion. It is an enigma how lymphocytes are able to undergo this seemingly …