Cadmium (Cd) is a transition metal ion that is extremely harmful to human and animal
biological systems. Cd is a toxic substance that can accumulate in the food chain and cause …

Treg cells, best identified by the expression of the transcription factor FOXP3, play a crucial
role in maintaining self‐tolerance. Natural Treg cells constitute an independent thymus …

Background T cell development occurs within the highly specialized thymus. Cytotoxic CD8
T cells are critical in adaptive immunity by targeting virally infected or tumor cells. In this …

Human CD34+ hematopoietic precursor cells cultured on delta-like ligand 1 expressing OP9
(OP9-DL1) stromal cells differentiate to T lineage cells. The nature of the T cells generated in …

Natural killer (NK) T cells are innate CD1d-restricted immune cells involved in regulation of
immune tolerance, tumor immunity, and immunity to infectious pathogens. Human α-chain …

The thymus is central to the establishment of a functioning immune system. Here is the place
where T cells mature from hematopoietic progenitors, driven by mutual interactions of …

Engineered T cells are at the leading edge of clinical cell therapy. T cell therapies have had
a remarkable impact on patient care for a subset of hematological malignancies. This …

Hematopoietic progenitor cells derived from human embryonic stem cells (hESCs) develop
into diverse mature hematopoietic lineages, including lymphocytes. Whereas functional …

T‐cell differentiation is driven by a complex network of signals mainly derived from the
thymic epithelium. In this study we demonstrate in the human thymus that cortical epithelial …

T cells, as orchestrators of the adaptive immune response, serve important physiological
and potentially therapeutic roles, for example in cancer immunotherapy. T cells are readily …