Mitochondria are critical for brain development and homeostasis. Therefore, pathogenic
variation in the mitochondrial or nuclear genome which disrupts mitochondrial function …

Collectively, rare genetic diseases affect a significant number of individuals worldwide. In
this study, we have conducted whole-exome sequencing (WES) and identified underlying …

The search for biomarkers for autism spectrum disorder (henceforth autism) has received a
lot of attention due to their potential clinical relevance. The clinical and aetiological …

Neurodevelopmental and neurodegenerative disorders (NNDs) are a group of conditions
with a broad range of core and co-morbidities, associated with dysfunction of the central …

Cancer spatial and temporal heterogeneity fuels resistance to therapies. To realize the
routine assessment of cancer prognosis and treatment, we demonstrate the development of …

Microfluidic technology has largely benefited both fundamental biological research and
translational clinical diagnosis with its advantages in high-throughput, single-cell resolution …

Intellectual disability (ID) poses formidable challenges to individuals in acquiring knowledge
and performing daily activities. This condition often stems from a variety of factors, such as …

Artificial intelligence (AI) has emerged as a powerful tool to revolutionize the healthcare
sector, including drug delivery and development. This review explores the current and future …

Background The field of precision medicine endeavors to transform the healthcare industry
by advancing individualised strategies for diagnosis, treatment modalities, and predictive …

Modern research has proven that the “typical patient” requiring standardized treatments
does not exist, reflecting the need for more personalized approaches for managing …