Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

As one of the most common metastatic sites of malignancies, bone has a unique
microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated …

Androgen receptor (AR) signaling is a distinctive feature of prostate carcinoma (PC) and
represents the major therapeutic target for treating metastatic prostate cancer (mPC) …

Background Platinum resistance is a major challenge in the clinical treatment of advanced
ovarian cancer (OC). Accumulating evidence shows that the tumor-promotive M2 …

Various preclinical models have been developed to clarify the pathophysiology of prostate
cancer (PCa). Traditional PCa cell lines from clinical metastatic lesions, as exemplified by …

FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly
regulating cell proliferation, survival, migration and differentiation during development and …

Patients with advanced prostate cancer often develop bone metastases, leading to bone
pain, skeletal fracture, and increased mortality. Bone provides a hospitable …

Types of Cell Culture Media Animal cells can be cultured either using a completely natural
medium or an artificial/synthetic medium along with some natural products. Natural Media …

Recurrent fusions of ETS genes are considered driving mutations in a diverse array of
cancers, including Ewing's sarcoma, acute myeloid leukemia, and prostate cancer. We …

Nanomedicines have significant potential for cancer treatment. Although the majority of
nanomedicines currently tested in clinical trials utilize simple, biocompatible liposome …