Recent advances in non-small cell lung cancer targeted therapy; an update review
Lung cancer continues to be the leading cause of cancer-related death worldwide. In the last
decade, significant advancements in the diagnosis and treatment of lung cancer, particularly …
decade, significant advancements in the diagnosis and treatment of lung cancer, particularly …
Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies
Renin-angiotensin-aldosterone system (RAAS) is a vital system of human body, as it
maintains plasma sodium concentration, arterial blood pressure and extracellular volume …
maintains plasma sodium concentration, arterial blood pressure and extracellular volume …
Preeclampsia: maternal systemic vascular disorder caused by generalized endothelial dysfunction due to placental antiangiogenic factors
T Tomimatsu, K Mimura, S Matsuzaki, M Endo… - International journal of …, 2019 - mdpi.com
Preeclampsia, a systemic vascular disorder characterized by new-onset hypertension and
proteinuria after 20 weeks of gestation, is the leading cause of maternal and perinatal …
proteinuria after 20 weeks of gestation, is the leading cause of maternal and perinatal …
Mechanisms of VEGF (vascular endothelial growth factor) inhibitor–associated hypertension and vascular disease
e2 Hypertension February 2018 target> 1 kinase receptor allowing for a broader indication
for use but with a greater potential for off-target effects. VSP inhibitors have been …
for use but with a greater potential for off-target effects. VSP inhibitors have been …
[HTML][HTML] Vascular toxicities with VEGF inhibitor therapies–focus on hypertension and arterial thrombotic events
RM Touyz, SMS Herrmann, J Herrmann - Journal of the American Society of …, 2018 - Elsevier
The vascular endothelial growth factor (VEGF) signaling pathway (VSP) fulfills a cardinal
role in endothelial cells and its inhibition has profound cardiovascular impact. This is true not …
role in endothelial cells and its inhibition has profound cardiovascular impact. This is true not …
TRPM7, magnesium, and signaling
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed chanzyme that possesses an ion channel permeable to the divalent cations …
expressed chanzyme that possesses an ion channel permeable to the divalent cations …
Bevacizumab-induced hypertension: Clinical presentation and molecular understanding
M Li, DL Kroetz - Pharmacology & therapeutics, 2018 - Elsevier
Bevacizumab is a vascular endothelial growth factor-A-specific angiogenesis inhibitor
indicated as an adjunct to chemotherapy for the treatment of several types of cancer …
indicated as an adjunct to chemotherapy for the treatment of several types of cancer …
VEGF receptor inhibitor-induced hypertension: emerging mechanisms and clinical implications
N Camarda, R Travers, VK Yang, C London… - Current oncology …, 2022 - Springer
Abstract Purpose of Review While vascular endothelial growth factor receptor inhibitors
(VEGFRis) have dramatically improved cancer survival, these drugs cause hypertension in a …
(VEGFRis) have dramatically improved cancer survival, these drugs cause hypertension in a …
Phase I, open-label, dose-escalation/dose-expansion study of lifirafenib (BGB-283), an RAF family kinase inhibitor, in patients with solid tumors
PURPOSE Lifirafenib is an investigational, reversible inhibitor of B-RAFV600E, wild-type A-
RAF, B-RAF, C-RAF, and EGFR. This first-in-human, phase I, dose-escalation/dose …
RAF, B-RAF, C-RAF, and EGFR. This first-in-human, phase I, dose-escalation/dose …
Clinical Approach to Cardiovascular Toxicity of Oral Antineoplastic Agents: JACC State-of-the-Art Review
VU Rao, DJ Reeves, AR Chugh, R O'Quinn… - Journal of the American …, 2021 - jacc.org
Precision medicine has ushered in a new era of targeted treatments for numerous
malignancies, leading to improvements in overall survival. Unlike traditional chemotherapy …
malignancies, leading to improvements in overall survival. Unlike traditional chemotherapy …