EZH2-mediated development of therapeutic resistance in cancer

P Kaur, E Shankar, S Gupta - Cancer Letters, 2024 - Elsevier
Enhancer of zeste homolog 2 (EZH2) regulates gene expression and plays a definite role in
cell proliferation, apoptosis, and senescence. Overexpression of EZH2 has been found in …

EZH2-interacting lncRNAs contribute to gastric tumorigenesis; a review on the mechanisms of action

H Mohebbi, R Esbati, RA Hamid, R Akhavanfar… - Molecular Biology …, 2024 - Springer
Gastric cancer (GC) remains one of the deadliest malignancies worldwide, demanding new
targets to improve its diagnosis and treatment. Long non-coding RNAs (lncRNAs) are …

E-cadherin loss drives diffuse-type gastric tumorigenesis via EZH2-mediated reprogramming

G Zou, Y Huang, S Zhang, KP Ko, B Kim… - Journal of Experimental …, 2024 - rupress.org
Diffuse-type gastric adenocarcinoma (DGAC) is a deadly cancer often diagnosed late and
resistant to treatment. While hereditary DGAC is linked to CDH1 mutations, the role of …

[HTML][HTML] Controllers of histone methylation-modifying enzymes in gastrointestinal cancers

L Li, Q Song, J Zhou, Q Ji - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Gastrointestinal (GI) cancers have been considered primarily genetic malignancies, caused
by a series of progressive genetic alterations. Accumulating evidence shows that histone …

Impact of Histone Lysine Methyltransferase SUV4-20H2 on Cancer Onset and Progression with Therapeutic Potential

S Papadaki, C Piperi - International Journal of Molecular Sciences, 2024 - mdpi.com
Histone lysine methyltransferase SUV4-20H2, a member of the suppressor of variegation 4–
20 homolog (SUV4-20) family, has a critical impact on the regulation of chromatin structure …

Histone and DNA Methylation as Epigenetic Regulators of DNA Damage Repair in Gastric Cancer and Emerging Therapeutic Opportunities

K De Marco, P Sanese, C Simone, V Grossi - Cancers, 2023 - mdpi.com
Simple Summary Histone and DNA methylations are widely studied epigenetic marks in
gastric cancer. Methylation is involved in DNA damage repair (DDR) and can also regulate …

[HTML][HTML] Identification and Validation of a Cancer-Testis Antigen-Related Signature to Predict the Prognosis in Stomach Adenocarcinoma

G Bian, J Cao, W Li, D Huang, X Ding, X Zang… - Journal of …, 2024 - ncbi.nlm.nih.gov
Background: Stomach adenocarcinoma (STAD) is the fifth most common cancer and the
third leading cause of cancer-related deaths worldwide. Cancer-testis antigens (CTAs) …

siRNA-based therapy for gastric adenocarcinoma: what's next step?

DM Salman, TAM Mohammad - Pathology-Research and Practice, 2024 - Elsevier
Gastric cancer continues to have a high death rate despite advancements in their diagnosis
and treatment. Novel treatment techniques are thus desperately needed. This is where …

Chromatin remodeling-related PRDM1 increases stomach cancer proliferation and is counteracted by bromodomain inhibitor

YH Hung, HC Wang, MR Pan, LT Chen - Journal of Personalized …, 2024 - mdpi.com
Gastrointestinal (GI) cancers are some of the main public health threats to the world. Even
though surgery, chemotherapy, and targeted therapy are available for their treatments, these …

Role of ACLY in the development of gastric cancer under hyperglycemic conditions

K Sun, J Ning, K Jia, X Fan, H Li, J Ma… - Quantitative …, 2024 - Wiley Online Library
To investigate the impact of hyperglycemia on the prognosis of patients with gastric cancer
and identify key molecules associated with high glucose levels in gastric cancer …