[HTML][HTML] Discogenic low back pain: anatomy, pathophysiology and treatments of intervertebral disc degeneration

IL Mohd Isa, SL Teoh, NH Mohd Nor… - International journal of …, 2022 - mdpi.com
Intervertebral disc (IVD) degeneration is a major contributing factor for discogenic low back
pain (LBP), causing a significant global disability. The IVD consists of an inner core …

Treatment of intervertebral disc degeneration

J Xin, Y Wang, Z Zheng, S Wang, S Na… - Orthopaedic …, 2022 - Wiley Online Library
Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low
back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high …

[HTML][HTML] Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global …

ML Ferreira, K De Luca, LM Haile… - The Lancet …, 2023 - thelancet.com
Background Low back pain is highly prevalent and the main cause of years lived with
disability (YLDs). We present the most up-to-date global, regional, and national data on …

Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial

CMP Jones, RO Day, BW Koes, J Latimer, CG Maher… - The Lancet, 2023 - thelancet.com
Background Opioid analgesics are commonly used for acute low back pain and neck pain,
but supporting efficacy data are scarce. We aimed to investigate the efficacy and safety of a …

[HTML][HTML] Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: A systematic analysis of the Global …

GBD 2021 Low Back Pain … - The Lancet …, 2023 - ncbi.nlm.nih.gov
Background Low back pain is highly prevalent and the main cause of years lived with
disability (YLDs). We present the most up-to-date global, regional, and national data on …

[HTML][HTML] Global, regional and national burden of low back pain 1990–2019: a systematic analysis of the Global Burden of Disease study 2019

S Chen, M Chen, X Wu, S Lin, C Tao, H Cao… - Journal of orthopaedic …, 2022 - Elsevier
Background To comprehensively analyze the global level and trends of prevalence,
incidence and years lived with disability (YLDs) for low back pain (LBP) from 1990 to 2019 …

[HTML][HTML] Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc

S Chen, X Wu, Y Lai, D Chen, X Bai, S Liu, Y Wu… - Bone research, 2022 - nature.com
Intervertebral disc (IVD) degeneration (IVDD) is the main cause of low back pain with major
social and economic burdens; however, its underlying molecular mechanisms remain poorly …

New generation psychological treatments in chronic pain

LM McCracken, L Yu, KE Vowles - bmj, 2022 - bmj.com
Chronic pain conditions are common and have a considerable impact on health and
wellbeing. This impact can be reduced by cognitive behavioral therapy (CBT), the most …

[HTML][HTML] Artificial intelligence-driven prediction modeling and decision making in spine surgery using hybrid machine learning models

B Saravi, F Hassel, S Ülkümen, A Zink… - Journal of Personalized …, 2022 - mdpi.com
Healthcare systems worldwide generate vast amounts of data from many different sources.
Although of high complexity for a human being, it is essential to determine the patterns and …

Evaluation of cognitive behavioral therapy on improving pain, fear avoidance, and self‐efficacy in patients with chronic low back pain: a systematic review and meta …

J Yang, WLA Lo, F Zheng, X Cheng… - Pain Research and …, 2022 - Wiley Online Library
Background. Cognitive‐behavioral therapy (CBT) is commonly adopted in pain
management programs for patients with chronic low back pain (CLBP). However, the …