[HTML][HTML] An update on reactive astrocytes in chronic pain
T Li, X Chen, C Zhang, Y Zhang, W Yao - Journal of neuroinflammation, 2019 - Springer
Chronic pain is a critical clinical problem with an increasing prevalence. However, there are
limited effective prevention measures and treatments for chronic pain. Astrocytes are the …
limited effective prevention measures and treatments for chronic pain. Astrocytes are the …
Metal drugs and the anticancer immune response
B Englinger, C Pirker, P Heffeter, A Terenzi… - Chemical …, 2018 - ACS Publications
The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
Breaking barriers to novel analgesic drug development
AS Yekkirala, DP Roberson, BP Bean… - Nature reviews Drug …, 2017 - nature.com
Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …
[HTML][HTML] Interleukin-6: an emerging regulator of pathological pain
YQ Zhou, Z Liu, ZH Liu, SP Chen, M Li… - Journal of …, 2016 - Springer
Interleukin-6 is an inflammatory cytokine with wide-ranging biological effects. It has been
widely demonstrated that neuroinflammation plays a critical role in the development of …
widely demonstrated that neuroinflammation plays a critical role in the development of …
[HTML][HTML] A review of cytokine-based pathophysiology of Long COVID symptoms
RN Low, RJ Low, A Akrami - Frontiers in Medicine, 2023 - frontiersin.org
The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with
initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is …
initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is …
Emerging biomarkers, tools, and treatments for diabetic polyneuropathy
GJ Bönhof, C Herder, A Strom, N Papanas… - Endocrine …, 2019 - academic.oup.com
Diabetic neuropathy, with its major clinical sequels, notably neuropathic pain, foot ulcers,
and autonomic dysfunction, is associated with substantial morbidity, increased risk of …
and autonomic dysfunction, is associated with substantial morbidity, increased risk of …
The role of microglia in the pathobiology of neuropathic pain development: what do we know?
H Zhao, A Alam, Q Chen, M A. Eusman… - BJA: British Journal …, 2017 - academic.oup.com
Neuropathic pain, a maladaptive and chronic condition that can develop after a lesion or
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …
The molecular neurobiology of chronic pain–induced depression
The increasing number of individuals with comorbidities poses an urgent need to improve
the management of patients with multiple co-existing diseases. Among these comorbidities …
the management of patients with multiple co-existing diseases. Among these comorbidities …
Crosstalk between the nociceptive and immune systems in host defence and disease
Nociceptors and immune cells both protect the host from potential threats to homeostasis.
There is growing evidence for bidirectional signalling between these two systems, and the …
There is growing evidence for bidirectional signalling between these two systems, and the …
The role of glia in the spinal cord in neuropathic and inflammatory pain
EA Old, AK Clark, M Malcangio - Pain control, 2015 - Springer
Chronic pain, both inflammatory and neuropathic, is a debilitating condition in which the
pain experience persists after the painful stimulus has resolved. The efficacy of current …
pain experience persists after the painful stimulus has resolved. The efficacy of current …