Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

Background Global but predictable changes impact the DNA methylome as we age, acting
as a type of molecular clock. This clock can be hastened by conditions that decrease …

Efficient control of energy metabolic homeostasis, enhanced stress resistance, and qualified
cellular housekeeping are the hallmarks of improved healthspan and extended lifespan …

Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

Increased oxidative stress has been associated with the aging process. However, recent
studies have revealed that a low-level oxidative stress can even extend the lifespan of …

Target of rapamycin (TOR) is an evolutionarily conserved nutrient-sensing protein kinase
that regulates growth and metabolism in all eukaryotic cells. Studies in flies, worms, yeast …

Aging is characterized by an increasing morbidity and functional decline that eventually
results in the death of an organism. Aging is the largest risk factor for numerous human …

According to life‐history theory, growth rates are subject to strong directional selection due
to reproductive and survival advantages associated with large adult body size. Yet, growth is …

Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that
elicits diverse aspects of the adaptive starvation response. Among its effects, FGF21 induces …