Comparison of Equimolar Doses of Mannitol and Hypertonic Sal... : Medicine Comparison of
Equimolar Doses of Mannitol and Hypertonic Saline for the Treatment of Elevated Intracranial …

Every 15 seconds someone suffers a traumatic brain injury (TBI) in the United States. TBI
causes more deaths in males< 35 years old than all other diseases combined, and it is …

Serum osmolality is the sum of the osmolalities of every single dissolved particle in the blood
such as sodium and associated anions, potassium, glucose, and urea. Under normal …

Hyperosmotic therapy is commonly used to treat intracranial hypertension in traumatic brain
injury patients. Unfortunately, hyperosmolality also affects other organs. An increase in …

The blood–brain barrier (BBB) plays an irreplaceable role in protecting the central nervous
system (CNS) from bloodborne pathogens. However, the BBB complicates the treatment of …

Introduction The optimal approach to fluid management in critically ill patients is highly
debated. Fluid resuscitation using hypertonic saline was used in the past for more than thirty …

Background Hypertonic saline (HS) has been used clinically for treatment of cerebral edema
for decades. Previously we have demonstrated that HS alleviates cerebral edema via …

There is a controversy about the effects of hypertonic saline (HS) used for brain relaxation in
patients requiring craniotomies. We conducted a meta-analysis to compare the efficacy of …

The appropriate use of medications during Emergency Neurological Life Support (ENLS) is
essential to optimize patient care. Important considerations when choosing the appropriate …

The appropriate use of medications during Emergency Neurological Life Support (ENLS) is
essential to optimize patient care. Important considerations when choosing the appropriate …