[HTML][HTML] Targeting extracellular nutrient dependencies of cancer cells

J Garcia-Bermudez, RT Williams, R Guarecuco… - Molecular …, 2020 - Elsevier
Background Cancer cells rewire their metabolism to meet the energetic and biosynthetic
demands of their high proliferation rates and environment. Metabolic reprogramming of …

Acetate dependence of tumors

SA Comerford, Z Huang, X Du, Y Wang, L Cai… - Cell, 2014 - cell.com
Acetyl-CoA represents a central node of carbon metabolism that plays a key role in
bioenergetics, cell proliferation, and the regulation of gene expression. Highly glycolytic or …

[HTML][HTML] The clinical use of PET with 11C-acetate

I Grassi, C Nanni, V Allegri, JJ Morigi… - American journal of …, 2012 - ncbi.nlm.nih.gov
The aim of this review is to evaluate clinical applications of 11 C-acetate positron emission
tomography (PET). Acetate is quickly metabolized into acetyl-CoA in human cells. In this …

SPECT and PET imaging of meningiomas

V Valotassiou, A Leondi, G Angelidis… - The Scientific World …, 2012 - Wiley Online Library
Meningiomas arise from the meningothelial cells of the arachnoid membranes. They are the
most common primary intracranial neoplasms and represent about 20% of all intracranial …

[HTML][HTML] Association of circulating short chain fatty acid levels with colorectal adenomas and colorectal cancer

F Genua, B Mirković, A Mullee, M Levy… - Clinical Nutrition …, 2021 - Elsevier
Background & aims Short chain fatty acid (SCFAs) are bacterially derived metabolites
suggested to have protective roles against colorectal cancer (CRC) development. However …

[HTML][HTML] Regulation of acetate utilization by monocarboxylate transporter 1 (MCT1) in hepatocellular carcinoma (HCC)

JY Jeon, M Lee, SH Whang, JW Kim, A Cho… - Oncology …, 2018 - ncbi.nlm.nih.gov
Altered energy metabolism is a biochemical fingerprint of cancer cells. Hepatocellular
carcinoma (HCC) shows reciprocal [18 F] fluorodeoxyglucose (FDG) and [11 C] acetate …

Loss of ACSS2 expression predicts poor prognosis in patients with gastric cancer

H Hur, YB Kim, IH Ham, D Lee - Journal of Surgical Oncology, 2015 - Wiley Online Library
Background Recent studies have demonstrated that acetyl‐CoA synthetase 2 (ACSS2)
plays a critical role in cancer cell survival; however, the role of ACSS2 in gastric …

11C-acetate positron emission tomography is more precise than 18F-fluorodeoxyglucose positron emission tomography in evaluating tumor burden and predicting …

M Chen, W Zhu, J Du, C Yang, B Han, D Zhou… - Scientific Reports, 2021 - nature.com
The optimal method of tumor burden evaluation in newly diagnosed multiple myeloma
(NDMM) is yet to be determined. This study aimed to compare the value of 11C-acetate …

An integrated metabonomics study to reveal the inhibitory effect and metabolism regulation of taurine on breast cancer

W Chen, Q Li, R Hou, H Liang, Y Zhang… - Journal of Pharmaceutical …, 2022 - Elsevier
Breast cancer is a common metastatic malignant tumor in women. Taurine has been found
to have anti-tumor effects on a variety of cancers. However, to the best of our knowledge, the …

Correlation of quantified metabolic activity in nonsmall cell lung cancer with tumor size and tumor pathological characteristics

MB Karam, A Doroudinia, B Behzadi, P Mehrian… - Medicine, 2018 - journals.lww.com
The aim of this study was to evaluate the relationship between maximum standardized
uptake value (SUV max) with tumor size and tumor pathological characteristics as well as …