Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where
they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood …

Pericytes, attached to the surface of capillaries, play an important role in regulating local
blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with …

The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

Millions of cardiomyocytes die immediately after myocardial infarction, regardless of whether
the culprit coronary artery undergoes prompt revascularization. Residual ischaemia in the …

Although cardiac action potential (AP) generation and propagation have traditionally been
attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable …

Arachidonic acid metabolites epoxyeicosatrienoates (EETs) and hydroxyeicosatetraenoates
(HETEs) are important regulators of myocardial blood flow and coronary vascular resistance …

Pericytes play an indispensable role in various organs and biological processes, such as
promoting angiogenesis, regulating microvascular blood flow, and participating in immune …

Coronary no-reflow (CNR) is a frequent phenomenon that develops in patients with ST-
segment elevation myocardial infarction (STEMI) following reperfusion therapy. CNR is …

Pericytes contract during myocardial ischemia resulting in capillary constriction and no
reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size …

No current treatments target microvascular reperfusion after stroke, which can contribute to
poor outcomes even after successful clot retrieval. The G protein–coupled receptor GPR39 …