The optical clarity of the cornea is essential for maintaining good visual acuity. Corneal
neovascularization, which is a major cause of vision loss worldwide, leads to corneal …

Abstract Background Matrix metalloproteinases (MMPs) are a family of ubiquitously
expressed zinc-dependent endopeptidases with broad substrate specificity and strictly …

The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of
DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular …

Matrix metalloproteinases (MMPs) are members of the metzincin group of proteases which
share the conserved zinc-binding motif in their catalytic active site. It was originally thought …

Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates
based on a conserved mechanism involving activation of an active site-bound water …

Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …

The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular
basement membrane (BM) and the interstitial ECM is identified as a crucial component of …

Proteases are important for multiple processes during malignant progression, including
tumor angiogenesis, invasion and metastasis. Recent evidence reveals that tumor …

The biological roles of the matrix metalloproteinases (MMPs) have been traditionally
associated with the degradation and turnover of most of the components of the extracellular …

Effective proteome-wide strategies that distinguish the N-termini of proteins from the N-
termini of their protease cleavage products would accelerate identification of the substrates …