When prevention fails, medicinal treatment of obesity may become a necessity. Any strategic
medicinal development must recognize that obesity is a chronic, stigmatized and costly …

In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …

Insulin and leptin are hypothesized to beadiposity signals' for the long-term regulation of
body weight by the brain. Accordingly, a change in the plasma levels of leptin or insulin …

Studies of mice and humans have revealed a number of genes that when mutated result in
severe obesity. We have studied a unique girl with early-onset obesity and a de novo …

Body weight gain frequently occurs during drug treatment of psychiatric disorders and is
often accompanied by increased appetite or food craving. While occurrence and time course …

Ghrelin is a peptide hormone produced and secreted from the stomach. Hypothalamic
injection of the peptide increases food intake but it is not known if the peptide affects other …

BACKGROUND & AIMS:: Pancreatic polypeptide (PP) belongs to a family of peptides
including neuropeptide Y and peptide YY. We examined the role of PP in the regulation of …

Prader-Willi syndrome (PWS) is a complex human genetic disease that arises from lack of
expression of paternally inherited imprinted genes on chromosome 15q11-q13 …

Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is
synthesized principally in the stomach and is released in response to fasting. Ghrelin is …

It is well known, although not well understood, that smoking and eating just do not go
together. Smoking is associated with decreased food intake and lower body weight …