Prevalence and mechanisms of skeletal muscle atrophy in metabolic conditions
Skeletal muscle atrophy is prevalent in a myriad of pathological conditions, such as
diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer's …
diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer's …
Slow or fast: Implications of myofibre type and associated differences for manifestation of neuromuscular disorders
Many neuromuscular disorders can have a differential impact on a specific myofibre type,
forming the central premise of this review. The many different skeletal muscles in mammals …
forming the central premise of this review. The many different skeletal muscles in mammals …
The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles
Prolonged high-fat diets (HFDs) can cause intramyocellular lipid (IMCL) accumulation that
may negatively affect muscle function. We investigated the duration of a HFD required to …
may negatively affect muscle function. We investigated the duration of a HFD required to …
Age-related skeletal muscle dysfunction is aggravated by obesity: an investigation of contractile function, implications and treatment
Obesity is a global epidemic and coupled with the unprecedented growth of the world's older
adult population, a growing number of individuals are both old and obese. Whilst both …
adult population, a growing number of individuals are both old and obese. Whilst both …
Alterations in skeletal muscle morphology and mechanics in juvenile male Sprague Dawley rats exposed to a high-fat high-sucrose diet
Although once a health concern largely considered in adults, the obesity epidemic is now
prevalent in pediatric populations. While detrimental effects on skeletal muscle function have …
prevalent in pediatric populations. While detrimental effects on skeletal muscle function have …
Age-related changes in isolated mouse skeletal muscle function are dependent on sex, muscle, and contractility mode
The present study aimed to simultaneously examine the age-related, muscle-specific, sex-
specific, and contractile mode-specific changes in isolated mouse skeletal muscle function …
specific, and contractile mode-specific changes in isolated mouse skeletal muscle function …
A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca2+ release capacity in the skeletal muscle of aged mice
Obesity and aging reduce skeletal muscle contractile function. However, it remains unclear
whether obesity additively promotes muscle contractile dysfunction in the setting of aging. In …
whether obesity additively promotes muscle contractile dysfunction in the setting of aging. In …
The effects of diet composition and chronic obesity on muscle growth and function
LGO de Sousa, AG Marshall… - Journal of Applied …, 2021 - journals.physiology.org
Diet-induced obesity (DIO) is associated with glucose intolerance, insulin resistance (IR),
and an increase in intramyocellular lipids (IMCL), which may lead to disturbances in glucose …
and an increase in intramyocellular lipids (IMCL), which may lead to disturbances in glucose …
Does dietary-induced obesity in old age impair the contractile performance of isolated mouse soleus, extensor digitorum longus and diaphragm skeletal muscles?
Ageing and obesity independently have been shown to significantly impair isolated muscle
contractile properties, though their synergistic effects are poorly understood. We uniquely …
contractile properties, though their synergistic effects are poorly understood. We uniquely …
Influence of obesity and type 2 diabetes on calcium handling by skeletal muscle: spotlight on the sarcoplasmic reticulum and mitochondria
H Eshima - Frontiers in Physiology, 2021 - frontiersin.org
Obesity and diabetes have been shown to interfere with energy metabolism and cause
peripheral insulin resistance in skeletal muscle. However, recent studies have focused on …
peripheral insulin resistance in skeletal muscle. However, recent studies have focused on …