The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates
the critical role for thyroid hormones during development, linear growth, and adult bone …

Obesity and its associated secondary complications are active areas of investigation in
search of effective treatments. As a result of this intensified research numerous differences …

Elevated thyroid‐stimulating hormone (TSH) and hypercholesterolemia commonly coexist,
as typically seen in hypothyroidism, but there is no known mechanism directly linking the …

Studies in genetically modified mice have highlighted the importance of the hypothalamic–
pituitary–thyroid (HPT) axis during skeletal development and the maintenance of adult bone …

The TSH receptor expressed on the cell surface of thyroid follicular cells plays a pivotal role
in the regulation of thyroid status and growth of the thyroid gland. In recent years it has …

With the ever-increasing burden of obesity and Type 2 diabetes, it is generally
acknowledged that there remains a need for developing new therapeutics. One potential …

Berberine (BBR), a hypoglycemic agent, has shown beneficial metabolic effects for anti-
diabetes, but its precise mechanism was unclear. Glucagon-like peptide-1 (GLP-1) is …

By proposing TSH as a key negative regulator of bone turnover, recent studies in TSH
receptor (TSHR) null mice challenged the established view that skeletal responses to …

The function of thyrotropin (TSH) in the thyroid gland is mediated by thyrotropin receptor
(TSHR). In addition to the thyroid, TSHR expression has been described in some non …

We have shown recently that by acting on the thyroid-stimulating hormone (TSH) receptor
(TSHR), TSH negatively regulates osteoclast differentiation. Both heterozygotic and …