There has been recent renewed interest in studying human early embryonic development.
The advent of improved culture conditions to maintain blastocysts in vitro for an extended …

Reproduction involves a wide range of biological processes, including organ formation and
development, neuroendocrine regulation, hormone production, and meiosis and mitosis …

Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Germline commitment following primordial germ cell (PGC) specification during early human
development establishes an epigenetic programme and competence for gametogenesis …

In vitro gametogenesis, the process of generating gametes from pluripotent cells in culture,
is a powerful tool for improving our understanding of germ cell development and an …

Epigenetic reprogramming resets parental epigenetic memories and differentiates
primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia. This process …

Recent studies show that pre-follicular mouse oogenesis takes place in germline cysts,
highly conserved groups of oogonial cells connected by intercellular bridges that develop as …

Human primordial germ cells (hPGCs), the precursors of sperm and eggs, are specified
during weeks 2− 3 after fertilization. Few studies on ex vivo and in vitro cultured human …

Human in vitro oogenesis provides a framework for clarifying the mechanism of human
oogenesis. To create its benchmark, it is vital to promote in vitro oogenesis using a model …

In vitro oogenesis is key to elucidating the mechanism of human female germ‐cell
development and its anomalies. Accordingly, pluripotent stem cells have been induced into …