Abnormal fetal growth, both growth restriction and overgrowth, is associated with perinatal
complications and an increased risk of metabolic and cardiovascular disease later in life …

Maternal obesity is growing in prevalence and is associated with increased morbidity and
mortality for both mother and child. Women who are obese during pregnancy have a greater …

Abstract Knowledge of the consequences of maternal obesity in human placental fatty acids
(FA) transport and metabolism is limited. Animal studies suggest that placental uptake of …

Inhibition of mammalian target of rapamycin (mTOR) signaling in cultured human primary
trophoblast cells reduces the activity of key placental amino acid transporters. However, the …

The activity of placental amino acid transporters is decreased in intrauterine growth
restriction (IUGR), but the underlying regulatory mechanisms have not been established …

Background: Fetal growth and development require n–3 (omega-3) long-chain
polyunsaturated fatty acids, but mechanisms for their placental transfer are not well …

Maternal obesity and gestational diabetes (GDM) are conditions associated with fetal
overgrowth and excessive fat accumulation in the fetus, implicating an increased placental …

The placenta is a key organ in programming the fetus for later disease. This review outlines
nine of many structural and physiological features of the placenta which are associated with …

Both in-vitro and human in-vivo studies using labeled fatty acids (FAs) reported a
preferential placental–fetal transfer of long-chain polyunsaturated fatty acids, although the …

Abstract Interleukin-1β (IL-1β) promotes insulin resistance in tissues such as liver and
skeletal muscle; however the influence of IL-1β on placental insulin signaling is unknown …