Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

DNA sequencing-based studies of neurodevelopmental disorders (NDDs) have identified a
wide range of genetic determinants. However, a comprehensive analysis of these data, in …

Tissue-specific regulatory regions harbor substantial genetic risk for disease. Because brain
development is a critical epoch for neuropsychiatric disease susceptibility, we characterized …

Chromatin is highly dynamic, undergoing continuous global changes in its structure and
type of histone and DNA modifications governed by processes such as transcription, repair …

The dynamic changes in chromatin conformation alter the organization and structure of the
genome and further regulate gene transcription. Basically, the chromatin structure is …

Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

Chromatin remodeling factor BAF155 is an important regulator of many biological
processes. As a core and scaffold subunit of the BAF (SWI/SNF-like) complex, BAF155 is …

DNA replication stress is a major source of DNA damage, including double-stranded breaks
that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can …

Objective Neurodevelopmental diseases are common disorders caused by the disruption of
essential neurodevelopmental processes. Recent human exome sequencing and genome …