[HTML][HTML] Regulation of adult neurogenesis in mammalian brain
Adult neurogenesis is a multistage process by which neurons are generated and integrated
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …
into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two …
[HTML][HTML] The emerging role of chromatin remodelers in neurodevelopmental disorders: a developmental perspective
B Mossink, M Negwer, D Schubert… - Cellular and Molecular …, 2021 - Springer
Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …
[HTML][HTML] Landscape of mSWI/SNF chromatin remodeling complex perturbations in neurodevelopmental disorders
AM Valencia, A Sankar, PJ van der Sluijs… - Nature Genetics, 2023 - nature.com
DNA sequencing-based studies of neurodevelopmental disorders (NDDs) have identified a
wide range of genetic determinants. However, a comprehensive analysis of these data, in …
wide range of genetic determinants. However, a comprehensive analysis of these data, in …
[HTML][HTML] Genetic control of expression and splicing in developing human brain informs disease mechanisms
Tissue-specific regulatory regions harbor substantial genetic risk for disease. Because brain
development is a critical epoch for neuropsychiatric disease susceptibility, we characterized …
development is a critical epoch for neuropsychiatric disease susceptibility, we characterized …
Sentinels of chromatin: chromodomain helicase DNA-binding proteins in development and disease
A Alendar, A Berns - Genes & Development, 2021 - genesdev.cshlp.org
Chromatin is highly dynamic, undergoing continuous global changes in its structure and
type of histone and DNA modifications governed by processes such as transcription, repair …
type of histone and DNA modifications governed by processes such as transcription, repair …
[HTML][HTML] Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration
D Jiang, T Li, C Guo, TS Tang, H Liu - Cell & Bioscience, 2023 - Springer
The dynamic changes in chromatin conformation alter the organization and structure of the
genome and further regulate gene transcription. Basically, the chromatin structure is …
genome and further regulate gene transcription. Basically, the chromatin structure is …
Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex
DJ Di Bella, N Domínguez-Iturza, JR Brown, P Arlotta - Neuron, 2024 - cell.com
Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …
RBM15 modulates the function of chromatin remodeling factor BAF155 through RNA methylation in developing cortex
Y Xie, R Castro-Hernández, G Sokpor, L Pham… - Molecular …, 2019 - Springer
Chromatin remodeling factor BAF155 is an important regulator of many biological
processes. As a core and scaffold subunit of the BAF (SWI/SNF-like) complex, BAF155 is …
processes. As a core and scaffold subunit of the BAF (SWI/SNF-like) complex, BAF155 is …
Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability
M Mognato, S Burdak-Rothkamm… - … Research/Reviews in …, 2021 - Elsevier
DNA replication stress is a major source of DNA damage, including double-stranded breaks
that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can …
that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can …
Arid1a regulates neural stem/progenitor cell proliferation and differentiation during cortical development
X Liu, SK Dai, PP Liu, CM Liu - Cell Proliferation, 2021 - Wiley Online Library
Objective Neurodevelopmental diseases are common disorders caused by the disruption of
essential neurodevelopmental processes. Recent human exome sequencing and genome …
essential neurodevelopmental processes. Recent human exome sequencing and genome …