Memory is essential in defining our identity by guiding behavior based on past experiences.
However, aging leads to declining memory, disrupting older adult's lives. Memories are …

Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …

The locus coeruleus is the initial site of Alzheimer's disease neuropathology, with
hyperphosphorylated Tau appearing in early adulthood followed by neurodegeneration in …

Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …

Abstract Changes in dopaminergic neuromodulation play a key role in adult memory
decline. Recent research has also implicated noradrenaline in shaping late-life memory …

Autopsy data indicate that the locus coeruleus (LC) is one of the first sites in the brain to
accumulate hyperphosphorylated tau pathology, with the rostral part possibly being more …

Many believe that engaging in novel and mentally challenging activities promotes brain
health and prevents Alzheimer's disease in later life. However, mental stimulation may also …

A growing body of evidence demonstrates the important role of the noradrenergic system in
the pathogenesis of many neurodegenerative processes, especially Alzheimer's disease …

Response inhibition is a core executive function enabling adaptive behavior in dynamic
environments. Human and animal models indicate that inhibitory control and control …

Background Degeneration of the locus coeruleus (LC) noradrenergic system contributes to
clinical symptoms in Alzheimer's disease (AD) and Parkinson's disease (PD). Diffusion …