A review of respiratory anatomical development, air flow characterization and particle deposition

MS Islam, G Paul, HX Ong, PM Young, YT Gu… - International journal of …, 2020 - mdpi.com
The understanding of complex inhalation and transport processes of pollutant particles
through the human respiratory system is important for investigations into dosimetry and …

Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract

F Huang, Q Zhu, X Zhou, D Gou, J Yu, R Li… - Advanced drug delivery …, 2021 - Elsevier
Effective evaluation and prediction of aerosol transport deposition in the human respiratory
tracts are critical to aerosol drug delivery and evaluation of inhalation products …

Computational modeling and validation of human nasal airflow under various breathing conditions

C Li, J Jiang, H Dong, K Zhao - Journal of biomechanics, 2017 - Elsevier
The human nose serves vital physiological functions, including warming, filtration,
humidification, and olfaction. These functions are based on transport phenomena that …

Computational analysis of aerosol-dynamics in a human whole-lung airway model

AV Kolanjiyil, C Kleinstreuer - Journal of Aerosol Science, 2017 - Elsevier
Prediction of the air-particle dynamics in human lungs can reveal critical deposition sites of
toxins or can determine best physical parameters for direct drug delivery and associated …

Anatomy matters: The role of the subject-specific respiratory tract on aerosol deposition—A CFD study

J Wedel, P Steinmann, M Štrakl, M Hriberšek… - Computer Methods in …, 2022 - Elsevier
The COVID-19 pandemic is one of the greatest challenges to humanity nowadays. COVID-
19 virus can replicate in the host's larynx region, which is in contrast to other viruses that …

Numerical investigation of the interaction, transport and deposition of multicomponent droplets in a simple mouth-throat model

X Chen, Y Feng, W Zhong, C Kleinstreuer - Journal of aerosol science, 2017 - Elsevier
A basic analysis of inhaled multicomponent droplet-vapor interaction and subsequent
aerosol deposition is very important for the understanding of natural phenomena as well as …

An in silico inter-subject variability study of extra-thoracic morphology effects on inhaled particle transport and deposition

Y Feng, J Zhao, C Kleinstreuer, Q Wang, J Wang… - Journal of Aerosol …, 2018 - Elsevier
An understanding of human inter-subject variability is crucial for the implementation of
personalized pulmonary drug delivery as well as exposure assessment of airborne …

Prediction of the carrier shape effect on particle transport, interaction and deposition in two dry powder inhalers and a mouth-to-G13 human respiratory system: A CFD …

J Zhao, A Haghnegahdar, Y Feng, A Patil… - Journal of Aerosol …, 2022 - Elsevier
Documentation of comparability between generic inhaler designs and the reference listed
drug (RLD) inhalers is essential for regulatory approval of the products. Such assessments …

An overview of experiments and numerical simulations on airflow and aerosols deposition in human airways and the role of bioaerosol motion in COVID-19 …

JK Mutuku, WC Hou, WH Chen - Aerosol and Air Quality Research, 2020 - aaqr.org
Determining the hotspots and deposition efficiencies (DEs) for aerosols in human airways is
important for both research and medical purposes. The complexity of the human airways …

Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part I: Theory and model validation

AV Kolanjiyil, C Kleinstreuer - Computers in biology and medicine, 2016 - Elsevier
Computational predictions of aerosol transport and deposition in the human respiratory tract
can assist in evaluating detrimental or therapeutic health effects when inhaling toxic …