Molecular and cellular changes during cancer progression resulting from genetic and epigenetic alterations
K Pruitt - Progress in Molecular Biology and Translational …, 2016 - Elsevier
Tumorigenesis is a complex process that involves a persistent dismantling of cellular
safeguards and checkpoints. These molecular and cellular changes that accumulate over …
safeguards and checkpoints. These molecular and cellular changes that accumulate over …
Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma
AR Conery, RC Centore, A Neiss, PJ Keller, S Joshi… - Elife, 2016 - elifesciences.org
Pharmacological inhibition of chromatin co-regulatory factors represents a clinically
validated strategy to modulate oncogenic signaling through selective attenuation of gene …
validated strategy to modulate oncogenic signaling through selective attenuation of gene …
AML with translocation t (8; 16)(p11; p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features
T Haferlach, A Kohlmann, HU Klein, C Ruckert… - Leukemia, 2009 - nature.com
Balanced chromosomal rearrangements define distinct entities in acute myeloid leukemia
(AML). Here, we present 13 AML cases with t (8; 16)(p11; p13) with observed low incidence …
(AML). Here, we present 13 AML cases with t (8; 16)(p11; p13) with observed low incidence …
Acute myeloid leukaemia with 8p11 (MYST3) rearrangement: an integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogenetique …
C Gervais, A Murati, C Helias, S Struski, A Eischen… - Leukemia, 2008 - nature.com
Thirty cases of acute myeloid leukaemia (AML) with MYST histone acetyltransferase 3
(MYST3) rearrangement were collected in a retrospective study from 14 centres in France …
(MYST3) rearrangement were collected in a retrospective study from 14 centres in France …
Targeting both BET and CBP/EP300 proteins with the novel dual inhibitors NEO2734 and NEO1132 leads to anti‐tumor activity in multiple myeloma
KR Ryan, F Giles, GJ Morgan - European Journal of …, 2021 - Wiley Online Library
Objectives Two promising epigenetic therapeutic targets have emerged for the treatment of
hematologic malignancies, BET and CBP/EP300 proteins. Several studies have shown that …
hematologic malignancies, BET and CBP/EP300 proteins. Several studies have shown that …
[HTML][HTML] High frequency of mosaic CREBBP deletions in Rubinstein–Taybi syndrome patients and mapping of somatic and germ-line breakpoints
C Gervasini, P Castronovo, A Bentivegna, F Mottadelli… - Genomics, 2007 - Elsevier
Rubinstein–Taybi syndrome (RSTS) is a rare malformation disorder caused by mutations in
the closely related CREBBP and EP300 genes, accounting respectively for up to 60 and 3 …
the closely related CREBBP and EP300 genes, accounting respectively for up to 60 and 3 …
[HTML][HTML] Two novel variants of MOZ-CBP fusion transcripts in spontaneously remitted infant leukemia with t (1; 16; 8)(p13; p13; p11), a new variant of t (8; 16)(p11; p13)
Translocation t (8; 16)(p11; p13) involving the MOZ/MYST3 gene (8p11) and the
CBP/CREBBP gene (16p13) is associated with the FAB M4/M5 subtype of acute myeloid …
CBP/CREBBP gene (16p13) is associated with the FAB M4/M5 subtype of acute myeloid …
急性白血病预后不良相关基因研究进展
包书萌， 李永哲 - 国际检验医学杂志, 2008 - cqvip.com
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[PDF][PDF] A novel specific signature of pediatric MOZ-CBP acute myeloid leukemia
S Serravalle, F Melchionda, A Astolfi, V Libri… - Leukemia …, 2010 - sfera.unife.it
The reciprocal chromosomal rearrangement t (8; 16)(p11; p13) is rare both in adult and
pediatric acute myeloid leukemias (AML) accounting 0.2–0.4% of de novo AML and 6.5% of …
pediatric acute myeloid leukemias (AML) accounting 0.2–0.4% of de novo AML and 6.5% of …
[HTML][HTML] Fatal outcome of a rare acute myeloid leukemia with t (8; 16)(p11. 2; p13. 3) and KAT6A:: CREBBP gene fusion in a young man
A Spałek, A Bartkowska-Chrobok… - … , Transfusion and Cell …, 2024 - Elsevier
Acute myeloid leukemia (AML) with t (8; 16)(p11; p13)/KAT6A:: CREBBP is a very rare
condition that accounts for less than 0.1% of de novo AML cases. 1 According to the …
condition that accounts for less than 0.1% of de novo AML cases. 1 According to the …