Many species of ganglioside GM1, differing for the sialic acid and ceramide content, have
been characterized and their physico-chemical properties have been studied in detail since …

Cellular membranes exhibit a fascinating variety of different morphologies, which are
continuously remodeled by transformations of membrane shape and topology. This …

GM2 gangliosidoses are a group of pathologies characterized by GM2 ganglioside
accumulation into the lysosome due to mutations on the genes encoding for the β …

Gangliosides, sialylated glycosphingolipids, found on all vertebrate cells and tissues, are
major molecular determinants on the surfaces of vertebrate nerve cells. Composed of a …

Lipids, defined by low solubility in water and high solubility in nonpolar solvents, can be
classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols …

Sphingolipids are a class of lipids highly enriched in the central nervous system (CNS),
which shows great diversity and complexity, and has been implicated in CNS development …

Cognitive processes, particularly learning and memory, are crucial brain mechanisms
mediating the successful adaptation of individuals to constantly changing environmental …

Nervonic acid, a 24-carbon fatty acid with only one double bond at the 9th carbon (C24: 1n-
9), is abundant in the human brain, liver, and kidney. It not only functions in free form but …

Diffusion and interaction dynamics of molecules at the plasma membrane play an important
role in cellular signaling and are suggested to be strongly associated with the actin …

This review begins by attempting to recount some of the pioneering discoveries that first
identified the presence of gangliosides in the nervous system, their structures and …