Simulated biological fluids–a systematic review of their biological relevance and use in relation to inhalation toxicology of particles and fibres
E Innes, HHP Yiu, P McLean, W Brown… - Critical Reviews in …, 2021 - Taylor & Francis
The use of simulated biological fluids (SBFs) is a promising in vitro technique to better
understand the release mechanisms and possible in vivo behaviour of materials, including …
understand the release mechanisms and possible in vivo behaviour of materials, including …
Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways
AL Garland, WG Walton, RD Coakley… - Proceedings of the …, 2013 - National Acad Sciences
The ability to maintain proper airway surface liquid (ASL) volume homeostasis is vital for
mucus hydration and clearance, which are essential aspects of the mammalian lung's innate …
mucus hydration and clearance, which are essential aspects of the mammalian lung's innate …
Pathogenicity and virulence of Aspergillus fumigatus
Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major
cause of morbidity and mortality globally. Compromised lung defences arising from …
cause of morbidity and mortality globally. Compromised lung defences arising from …
Chitosan-based responsive hybrid nanogels for integration of optical pH-sensing, tumor cell imaging and controlled drug delivery
We report a new class of chitosan-based hybrid nanogels by in-situ immobilization of CdSe
quantum dots (QDs) in the chitosan–poly (methacrylic acid)(chitosan–PMAA) networks. The …
quantum dots (QDs) in the chitosan–poly (methacrylic acid)(chitosan–PMAA) networks. The …
Discovery of CFTR modulators for the treatment of cystic fibrosis
M Lopes-Pacheco, N Pedemonte… - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction Cystic fibrosis (CF) is a life-threatening inherited disease caused by mutations
in the gene encoding the CF transmembrane conductance regulator (CFTR) protein, an …
in the gene encoding the CF transmembrane conductance regulator (CFTR) protein, an …
In-situ immobilization of quantum dots in polysaccharide-based nanogels for integration of optical pH-sensing, tumor cell imaging, and drug delivery
We report a class of polysaccharide-based hybrid nanogels that can integrate the functional
building blocks for optical pH-sensing, cancer cell imaging, and controlled drug release into …
building blocks for optical pH-sensing, cancer cell imaging, and controlled drug release into …
Role of epithelial HCO3− transport in mucin secretion: lessons from cystic fibrosis
PM Quinton - American Journal of Physiology-Cell …, 2010 - journals.physiology.org
The invitation to present the 2010 Hans Ussing lecture for the Epithelial Transport Group of
the American Physiological Society offered me a unique, special, and very surprising …
the American Physiological Society offered me a unique, special, and very surprising …
The effect of CFTR modulators on airway infection in cystic fibrosis
The advent of Cystic fibrosis transmembrane receptor (CFTR) modulators in 2012 was a
critical event in the history of cystic fibrosis (CF) treatment. Unlike traditional therapies that …
critical event in the history of cystic fibrosis (CF) treatment. Unlike traditional therapies that …
Mechanisms of acid and base secretion by the airway epithelium
H Fischer, JH Widdicombe - The Journal of membrane biology, 2006 - Springer
One of the main functions of the airway epithelium is to inactivate and remove infectious
particles from inhaled air and thereby prevent infection of the distal lung. This function is …
particles from inhaled air and thereby prevent infection of the distal lung. This function is …
Airway surface liquid pH is not acidic in children with cystic fibrosis
Modulation of airway surface liquid (ASL) pH has been proposed as a therapy for cystic
fibrosis (CF). However, evidence that ASL pH is reduced in CF is limited and conflicting. The …
fibrosis (CF). However, evidence that ASL pH is reduced in CF is limited and conflicting. The …