Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease
in the world, yet there are still no approved pharmacological therapies to prevent or treat this …

Aims/hypothesis The aim of this study was to use Mendelian randomisation (MR) to identify
the causal risk factors for type 2 diabetes. Methods We first conducted a review of meta …

Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …

Background & Aims Non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and
obesity are epidemiologically correlated with each other but the causal inter-relationships …

Context Nonalcoholic fatty liver disease (NAFLD) prevalence is high, especially in patients
with obesity and type 2 diabetes, and is expected to rise steeply in the coming decades …

South Asians have a high prevalence of type 2 diabetes, even at a lower BMI. This review
sets out our perspective and hypothesis on the reasons for this. Emerging data from …

Obesity and type 2 diabetes are causally related, yet there is considerable heterogeneity in
the consequences of both conditions and the mechanisms of action are poorly defined. Here …

Passive permeability is a key property in drug disposition and delivery. It is critical for
gastrointestinal absorption, brain penetration, renal reabsorption, defining clearance …

Diabetes and its complications cause a heavy disease burden globally. Identifying
exposures, risk factors and molecular processes causally associated with the development …

OBJECTIVE Fat content and volume of liver and pancreas are associated with risk of
diabetes in observational studies; whether these associations are causal is unknown. We …