[HTML][HTML] Chemotherapy side-effects: not all DNA damage is equal

WMC van den Boogaard, DSJ Komninos, WP Vermeij - Cancers, 2022 - mdpi.com
Simple Summary The number of children and adults with cancer that are completely cured is
still increasing thanks to effective anti-cancer therapy, but they may be confronted with the …

[HTML][HTML] Chemotherapy-induced cognitive impairment and hippocampal neurogenesis: a review of physiological mechanisms and interventions

MJ Sekeres, M Bradley-Garcia… - International journal of …, 2021 - mdpi.com
A wide range of cognitive deficits, including memory loss associated with hippocampal
dysfunction, have been widely reported in cancer survivors who received chemotherapy …

Long-term trajectories of physical function decline in women with and without cancer

EMC Feliciano, S Vasan, J Luo, AM Binder… - JAMA …, 2023 - jamanetwork.com
Importance Patients with cancer experience acute declines in physical function,
hypothesized to reflect accelerated aging driven by cancer-related symptoms and effects of …

Senolytic treatment alleviates doxorubicin‐induced chemobrain

V Budamagunta, A Kumar, A Rani… - Aging cell, 2024 - Wiley Online Library
Doxorubicin (Dox), a widely used treatment for cancer, can result in chemotherapy‐induced
cognitive impairments (chemobrain). Chemobrain is associated with inflammation and …

Mechanisms of Hydroxyurea‐Induced Cellular Senescence: An Oxidative Stress Connection?

S Kapor, V Čokić, JF Santibanez - Oxidative medicine and …, 2021 - Wiley Online Library
Hydroxyurea (HU) is a water‐soluble antiproliferative agent used for decades in neoplastic
and nonneoplastic conditions. HU is considered an essential medicine because of its …

[HTML][HTML] Molecular mechanisms of aging and anti-aging strategies

Y Li, X Tian, J Luo, T Bao, S Wang, X Wu - Cell Communication and …, 2024 - Springer
Aging is a complex and multifaceted process involving a variety of interrelated molecular
mechanisms and cellular systems. Phenotypically, the biological aging process is …

Investigation of self-assembled poly (ethylene glycol)-poly (L-lactic acid) micelle as potential drug delivery system for poorly water soluble anticancer drug abemaciclib

Z Ansarinik, H Kiyani, M Yoosefian - Journal of Molecular Liquids, 2022 - Elsevier
Polymer-based drug delivery systems have the ability to organize stable self-assembled
nanocarriers containing hydrophobic cores allow to delivery of poorly water-soluble …

[HTML][HTML] Premature aging in childhood cancer survivors

J Kruseova, A Zichova… - Oncology …, 2023 - spandidos-publications.com
Progress in medicine has increased the survival time of children suffering from cancer;>
80% of patients survive for at least 5 years from the end of treatment. However, there are late …

[HTML][HTML] The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical …

IM Verdonck-de Leeuw, LHA Korsten… - Supportive Care in …, 2023 - Springer
Purpose The aim of this prospective cohort study was to estimate the relationship between
the course of HRQOL in the first 2 years after diagnosis and treatment of head and neck …

Analysis of Biological Aging and Risks of All-Cause and Cardiovascular Disease–Specific Death in Cancer Survivors

D Zhang, C Leeuwenburgh, D Zhou, Y Gong… - JAMA network …, 2022 - jamanetwork.com
Cancer is an age-related disease. In the United States, the median age at cancer diagnosis
is 66 years. 1 In older people diagnosed with cancer, aging2 and cancer treatment toxic …