Deadenylation of eukaryotic mRNA is a mechanism critical for mRNA function by influencing
mRNA turnover and efficiency of protein synthesis. Here, we review poly (A)-specific …

Poly (A) polymerase synthesizes poly (A) tails rapidly and processively only when the
substrate RNA is bound simultaneously by two stimulatory proteins, the cleavage and …

We have identified a 3′ exonuclease in HeLa cell extracts which deadenylates mammalian
mRNA and leaves the mRNA body intact after poly (A) removal. Only homopolymeric …

A HeLa cell 3'-exonuclease with properties of a mammalian mRNA poly (A) tail-removing
enzyme has been characterized. The exonuclease shows high specificity for the poly (A) tail …

< 1> Canis familiaris (isozymes A and B [1])[1]< 2> Rattus norvegicus (male rats [48];
Sprague-Dawley rats [40]; ST1A1 [40, 48]; AST IV [48]; aryl sulfotransferase IV [32, 48]; a …

We have described a cell-free system for studying mRNA degradation (Ross, J., and Kobs,
G.(1986) J. Mol. Biol. 188, 579-593). Using that system we found that human H4 histone …

At present, three enzymes are known which participate in regulation of polyadenylation and
polydeadenylation of eukaryotic mRNA: poly (A) polymerase, endoribonuclease TV and 2 …

An exoribonuclease from calf thymus which specifically cleaves poly (A) in the single-or in
the double-stranded form has been isolated and purified to homogeneity. The enzyme has a …

Publisher Summary This chapter discusses the multiplicity, cellular localization, and
regulation of poly (A) adding enzymes. It illustrates the poly (A) adding reactions that are …

Despite the discovery of an enzymatic activity catalyzing poly (A) synthesis as early as 1960,
1 the functional significance of this enzyme was not known until early 1970s when poly (A) …