Heparin is a negatively charged polysaccharide with various chain lengths and a hydrophilic
backbone. Due to its fascinating chemical and physical properties, nontoxicity …

Owing to the high mortality and the spread rate, the infectious disease caused by SARS-CoV-
2 has become a major threat to public health and social economy, leading to over 70 million …

Thrombotic complication has been an important symptom in critically ill patients with COVID-
19. It has not been clear whether the virus spike (S) protein can directly induce blood …

Background: COVID-19-associated coagulopathy (CAC) exacerbates the course of
coronavirus infection and contributes to increased mortality. Current recommendations for …

Low molecular weight heparin (LMWH) is a glycosaminoglycan long known for its
anticoagulant properties. In recent times, recent evidence has associated this drug with extra …

Severe imbalance in iron metabolism among SARS-CoV-2 infected patients is prominent in
every symptomatic (mild, moderate to severe) clinical phase of COVID-19. Phase-I–Hypoxia …

Unfractionated heparin has multiple pharmacological activities beyond anticoagulation.
These anti-inflammatory, anti-microbial, and mucoactive activities are shared in part by low …

Introduction Patients with COVID‐19 frequently exhibit a hypercoagulable state with high
thrombotic risk, particularly those admitted to intensive care units (ICU). Thromboprophylaxis …

Polysaccharides are complex macromolecules long regarded as energetic storage
resources or as components of plant and fungal cell walls. They have also been described …

Novel and efficient strategies need to be developed to interfere with the SARS-CoV-2 virus.
One of the most promising pharmaceutical targets is the nucleocapsid protein (N) …