Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Pain can be both a cause and a consequence of sleep deficiency. This bidirectional
relationship between sleep and pain has important implications for clinical management of …

Children who experience chronic stressors are vulnerable to emotional and physical health
problems across the lifespan. This phenomenon raises questions for scientists and …

Reciprocal signalling between immunocompetent cells in the central nervous system (CNS)
has emerged as a key phenomenon underpinning pathological and chronic pain …

Opioids produce strong analgesia but their use is limited by a paradoxical hypersensitivity
named opioid-induced hyperalgesia (OIH) that may be associated to analgesic tolerance. In …

Opioid use for pain management has dramatically increased, with little assessment of
potential pathophysiological consequences for the primary pain condition. Here, a short …

Toll-like receptor 4 (TLR4) recognizes exogenous pathogen-associated molecular patterns
(PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the …

Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …

The primate-exclusive MRGPRX2 G protein-coupled receptor (GPCR) has been suggested
to modulate pain and itch. Despite putative peptide and small-molecule MRGPRX2 agonists …

Drugs of abuse cause persistent alterations in synaptic plasticity that may underlie addiction
behaviors. Evidence suggests glial cells have an essential and underappreciated role in the …