OBJECTIVES: To identify research priorities in the management, epidemiology, outcome,
and pathophysiology of sepsis and septic shock. DESIGN: Shortly after publication of the …

The importance of fluid resuscitation therapy during the early stages of sepsis management
is a well-established principle. Current Surviving Sepsis Campaign (SSC) guidelines …

We read with interest the recent study by Bruno et al.[1], testing the hypothesis that providing
a single sublingual microcirculatory variable (percentage of perfused small vessels, sPPV) …

We have read with great interest the article by J. Duranteau and colleagues entitled “The
future of intensive care: the study of the microcirculation will help to guide our therapies”[1] …

In this work, we used a hybrid time domain near-infrared spectroscopy (TD-NIRS) and
diffuse correlation spectroscopy (DCS) device to retrieve hemoglobin and blood flow …

Background Impaired microcirculation is a cornerstone of sepsis development and leads to
reduced tissue oxygenation, influenced by fluid and catecholamine administration during …

According to Fick's principle, the total uptake of (or release of) a substance by tissues is the
product of blood flow and the difference between the arterial and the venous concentration …

Background Circulatory shock, defined as decreased tissue perfusion, leading to
inadequate oxygen delivery to meet cellular metabolic demands, remains a common …

We are grateful that Hilty et al.[1] found our recently published Direct Assessment of
Microcirculation In Shock (DAMIS) trial [2] as relevant enough to comment on. Clearly …

A lactate/albumin ratio (LAR) greater than 0.5 measured early in the course of pediatric
critical illness is associated with greater mortality. Whether the elevated LAR can be …