Dilated cardiomyopathy is conventionally defined as the presence of left ventricular or
biventricular dilatation or systolic dysfunction in the absence of abnormal loading conditions …

Polyguluronic acid (PG), a polysaccharide from alginate, possesses excellent bioactivities.
We prepared high-purity PG with 10.41 kDa molecular weight (Mw) and a 59 average …

Clinically, cardiac dysfunction is a key component of sepsis-induced multi-organ failure.
Mitochondria are essential for cardiomyocyte homeostasis, as disruption of mitochondrial …

Doxorubicin (DOX) is a broad-spectrum and highly efficient anticancer agent, but its clinical
implication is limited by lethal cardiotoxicity. Growing evidences have shown that alterations …

Cancer and cardiovascular disease are the leading causes of death worldwide. Recent
evidence suggests that these two life-threatening diseases share several features in disease …

Doxorubicin (DOX) is a potent chemotherapeutic agent used against several cancer types.
However, due to its cardiotoxic adverse effects, the use of this drug may be also life …

Cardiotoxicity remains a major limitation in the clinical utility of anthracycline
chemotherapeutics. Regulator of G-protein Signaling 7 (RGS7) and inflammatory markers …

Severe cardiotoxic effects limit the efficacy of doxorubicin (DOX) as a chemotherapeutic
agent. Activation of intracellular stress signaling networks, including p38 mitogen-activated …

Introduction: Obstructive sleep apnea (OSA) is frequently associated with a chronic
inflammatory state and cardiovascular/metabolic complications. The aim of this study was to …

The clinic application of doxorubicin (DOX) is severely limited by its severe cardiotoxicity.
Tripartite motif-containing protein 16 (TRIM16) has E3 ubiquitin ligase activity and is …