Modular microfluidics for life sciences
The advancement of microfluidics has enabled numerous discoveries and technologies in
life sciences. However, due to the lack of industry standards and configurability, the design …
life sciences. However, due to the lack of industry standards and configurability, the design …
Three‐dimensional multicellular biomaterial platforms for biomedical application
J Hao, C Qin, C Wu - Interdisciplinary Materials, 2023 - Wiley Online Library
Abstract The three‐dimensional (3D) multicellular platforms prepared by cells or
biomaterials have been widely applied in biomedical fields for the regeneration of complex …
biomaterials have been widely applied in biomedical fields for the regeneration of complex …
iPSC-derived three-dimensional brain organoid models and neurotropic viral infections
M Swingler, M Donadoni, A Bellizzi, S Cakir… - Journal of …, 2023 - Springer
Progress in stem cell research has revolutionized the medical field for more than two
decades. More recently, the discovery of induced pluripotent stem cells (iPSCs) has allowed …
decades. More recently, the discovery of induced pluripotent stem cells (iPSCs) has allowed …
Vascularized microfluidic models of major organ structures and cancerous tissues
A Rama Varma, P Fathi - Biomicrofluidics, 2023 - pubs.aip.org
Organ-on-a-chip devices are powerful modeling systems that allow researchers to
recapitulate the in vivo structures of organs as well as the physiological conditions those …
recapitulate the in vivo structures of organs as well as the physiological conditions those …
Complex in vitro model: A transformative model in drug development and precision medicine
L Wang, D Hu, J Xu, J Hu… - Clinical and Translational …, 2024 - Wiley Online Library
In vitro and in vivo models play integral roles in preclinical drug research, evaluation, and
precision medicine. In vitro models primarily involve research platforms based on cultured …
precision medicine. In vitro models primarily involve research platforms based on cultured …
Optogenetically modified human embryonic stem cell-derived otic neurons establish functional synaptic connection with cochlear nuclei
Y Chen, W Mu, Y Wu, J Xu, X Li, H Hu… - Journal of Tissue …, 2024 - journals.sagepub.com
Spiral ganglia neurons (SGNs) impairment can cause deafness. One important therapeutic
approach involves utilizing stem cells to restore impaired auditory circuitry. Nevertheless, the …
approach involves utilizing stem cells to restore impaired auditory circuitry. Nevertheless, the …
Applications of 3D organoids in toxicological studies: a comprehensive analysis based on bibliometrics and advances in toxicological mechanisms
H Yang, S Niu, M Guo, Y Xue - Archives of Toxicology, 2024 - Springer
A mechanism exploration is an important part of toxicological studies. However, traditional
cell and animal models can no longer meet the current needs for in-depth studies of …
cell and animal models can no longer meet the current needs for in-depth studies of …
Advances in 3D bioprinting for regenerative medicine applications
K Loukelis, N Koutsomarkos, AG Mikos… - Regenerative …, 2024 - academic.oup.com
Biofabrication techniques allow for the construction of biocompatible and biofunctional
structures composed from biomaterials, cells and biomolecules. Bioprinting is an emerging …
structures composed from biomaterials, cells and biomolecules. Bioprinting is an emerging …
Opportunities and Perspectives for Three Dimensional Culture of Mesenchymal Stem Cell-Derived Exosomes
G Lin, W Pan, Y He, X Yi, P Zhou, J Lu - Tissue Engineering Part B …, 2024 - liebertpub.com
Exosomes are nanosized extracellular vesicles (EVs) that participate in intercellular
communication through surface proteins and the delivery of internal cargo. The exosomes …
communication through surface proteins and the delivery of internal cargo. The exosomes …
Preparation of Controlled Multicompartmental Gel Microcarriers Based on Aqueous Two-Phase Emulsions for 3D Partitioned Cell Coculture In Vitro
H He, M Hong, F Yang, G Wang, Y Wang… - …, 2024 - ACS Publications
A facile method was proposed for preparing controllable multicompartment gel microcarriers
using an aqueous two-phase emulsion system. By leveraging the density difference …
using an aqueous two-phase emulsion system. By leveraging the density difference …