[HTML][HTML] Emerging roles and therapeutic potentials of sphingolipids in pathophysiology: Emphasis on fatty acyl heterogeneity

J Mu, SM Lam, G Shui - Journal of Genetics and Genomics, 2024 - Elsevier
Sphingolipids not only exert structural roles in cellular membranes, but also act as signaling
molecules in various physiological and pathological processes. A myriad of studies have …

Low-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development

L Zhang, J Zhao, SM Lam, L Chen, Y Gao, W Wang… - Nature Cell …, 2024 - nature.com
Lipids are indispensable for energy storage, membrane structure and cell signalling.
However, dynamic changes in various categories of endogenous lipids in mammalian early …

Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning

X Hu, M Sun, Q Chen, Y Zhao, N Liang, S Wang… - Nature …, 2023 - nature.com
MyoD is a skeletal muscle-specifically expressed transcription factor and plays a critical role
in regulating myogenesis during muscle development and regeneration. However, whether …

Acyl carrier protein OsMTACP2 confers rice cold tolerance at the booting stage

XL Hou, X Han, Y Meng, L Wang, W Zhang… - Plant …, 2024 - academic.oup.com
Low temperatures occurring at the booting stage in rice (Oryza sativa L.) often result in yield
loss by impeding male reproductive development. However, the underlying mechanisms by …

Metabolic pathway of Monounsaturated lipids revealed by In-Depth structural lipidomics by Mass Spectrometry

S Cheng, D Zhang, J Feng, Q Hu, A Tan, Z Xie, Q Chen… - Research, 2023 - spj.science.org
The study of lipid metabolism relies on the characterization of the lipidome, which is quite
complex due to the structure variations of the lipid species. New analytical tools have been …

Unraveling the mechanisms of cardiolipin function: The role of oxidative polymerization of unsaturated acyl chains

S Jang, S Javadov - Redox Biology, 2023 - Elsevier
Cardiolipin is a unique phospholipid of the inner mitochondrial membrane (IMM) as well as
in bacteria. It performs several vital functions such as resisting osmotic rupture and …

HPS6 Deficiency Leads to Reduced V-ATPase and Impaired Biogenesis of Lamellar Bodies in Alveolar Type II Cells

Z Hao, H Wang, Z Zhou, Q Yang, B Zhang… - American Journal of …, 2024 - atsjournals.org
Lamellar body (LB) is a tissue-specific lysosome-related organelle in type II alveolar cells,
which is the main site for the synthesis, storage and secretion of pulmonary surfactants …

DNA-PKcs phosphorylates cofilin2 to induce endothelial dysfunction and microcirculatory disorder in endotoxemic cardiomyopathy

Y Du, P Zhu, Y Li, J Yu, T Xia, X Chang, H Zhu, R Li… - Research, 2024 - spj.science.org
The presence of endotoxemia is strongly linked to the development of endothelial
dysfunction and disruption of myocardial microvascular reactivity. These factors play a …

Cardiac lipidomic profiles in mice undergo changes from fetus to adult

Z Pan, C Huang, X Zhu, N Li, H Huynh, J Xu, L Huang… - Life sciences, 2024 - Elsevier
Aims Lipids are essential cellular components with many important biological functions.
Disturbed lipid biosynthesis and metabolism has been shown to cause cardiac …

[HTML][HTML] Pgam5 aggravates hyperglycemia-induced myocardial dysfunction through disrupting Phb2-dependent mitochondrial dynamics

Y Chen, J Huang, H Zhou, J Lin… - International Journal of …, 2024 - ncbi.nlm.nih.gov
This study aims to elucidate the roles of Phosphoglycerate Mutase Family Member 5
(Pgam5) and Prohibitin 2 (Phb2) in the context of hyperglycemia-induced myocardial …