[HTML][HTML] Role and regulation of autophagy in cancer

R Rakesh, LC PriyaDharshini, KM Sakthivel… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Autophagy is an intracellular self-degradative mechanism which responds to cellular
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …

[HTML][HTML] A narrative review of acute pancreatitis and its diagnosis, pathogenetic mechanism, and management

Z Zheng, YX Ding, YX Qu, F Cao, F Li - Annals of translational …, 2021 - ncbi.nlm.nih.gov
Acute pancreatitis (AP) is an inflammatory disease that can progress to severe acute
pancreatitis (SAP), which increases the risk of death. AP is characterized by inappropriate …

New insights into the etiology, risk factors, and pathogenesis of pancreatitis in dogs: Potential impacts on clinical practice

H Cridge, SY Lim, H Algül… - Journal of Veterinary …, 2022 - Wiley Online Library
While most cases of pancreatitis in dogs are thought to be idiopathic, potential risk factors
are identified. In this article we provide a state‐of‐the‐art overview of suspected risk factors …

Comprehensive review on the pathogenesis of hypertriglyceridaemia-associated acute pancreatitis

M Qiu, X Zhou, M Zippi, H Goyal, Z Basharat… - Annals of …, 2023 - Taylor & Francis
It is well known, that the inflammatory process that characterizes acute pancreatitis (AP) can
lead to both pancreatic damage and systemic inflammatory response syndrome (SIRS) …

Body mass index, triglycerides, and risk of acute pancreatitis: a population-based study of 118 000 individuals

SEJ Hansen, CM Madsen, A Varbo… - The Journal of …, 2020 - academic.oup.com
Objective The incidence of acute pancreatitis is rising worldwide and currently no curative
treatment exists. Clarification of preventable risk factors is important for the reduction of …

GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFβR1/SMAD-2 pathway

F Duan, X Wang, H Wang, Y Wang, Y Zhang… - International …, 2022 - Elsevier
Severe acute pancreatitis (SAP), as a typical acute inflammatory injury disease, is one of the
acute gastrointestinal diseases with a remarkable mortality rate. Macrophages, typical …

Commensal Escherichia coli Aggravates Acute Necrotizing Pancreatitis through Targeting of Intestinal Epithelial Cells

J Zheng, L Lou, J Fan, C Huang, Q Mei… - Applied and …, 2019 - Am Soc Microbiol
ABSTRACT An increase of Escherichia-Shigella was previously reported in acute
necrotizing pancreatitis (ANP). We investigated whether Escherichia coli MG1655, an …

Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis

S Sun, Y Han, C Zhang, H Liu, B Wang… - Frontiers in Cell and …, 2022 - frontiersin.org
Background: Inflammatory disorder and acinar cell death contribute to the initiation and
progression of severe acute pancreatitis (SAP). Adenosine kinase (ADK) has potential …

Autophagy in acute pancreatitis: organelle interaction and microRNA regulation

X Yuan, J Wu, X Guo, W Li, C Luo, S Li… - Oxidative Medicine …, 2021 - Wiley Online Library
Acute pancreatitis (AP) is a common disorder with significant hospital admission and
mortality. Due to the unclarified pathological mechanism, there is still no effective and …

Deficient endoplasmic reticulum acetyl-CoA import in pancreatic acinar cells leads to chronic pancreatitis

MM Cooley, DDH Thomas, K Deans, Y Peng… - Cellular and Molecular …, 2021 - Elsevier
Background & Aims Maintaining endoplasmic reticulum (ER) proteostasis is essential for
pancreatic acinar cell function. Under conditions of severe ER stress, activation of …