The essential role of GSTP1 I105V polymorphism in the prediction of CDNB metabolism and toxicity: In silico and in vitro insights
H Lin, H Wu, H Li, A Song, W Yin - Toxicology in Vitro, 2023 - Elsevier
Humans are continuously exposed to toxic chemicals such as nitro-chlorobenzene (CDNB)
through occupation, water, and even the air we breathe. Due to the severe toxicity caused by …
through occupation, water, and even the air we breathe. Due to the severe toxicity caused by …
Effects of dose and human N-acetyltransferase 1 genetic polymorphism in benzidine metabolism and genotoxicity
Benzidine undergoes N-acetylation and following CYP1A2-catalyzed N-hydroxylation
undergoes O-acetylation catalyzed by N-acetyltransferase 1 (NAT1). Benzidine exposure is …
undergoes O-acetylation catalyzed by N-acetyltransferase 1 (NAT1). Benzidine exposure is …
Effect of N-acetyltransferase 2 genetic polymorphism on 4,4′-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress
MR Habil, RA Salazar-González, MA Doll… - Archives of …, 2023 - Springer
Methylenebis (2-chloroaniline) or MOCA is an aromatic amine used primarily in
polyurethane and rubber industry. MOCA has been linked to hepatomas in animal studies …
polyurethane and rubber industry. MOCA has been linked to hepatomas in animal studies …
N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen β-naphthylamine in cryopreserved human hepatocytes
MR Habil, RA Salazar-González, MA Doll… - Archives of toxicology, 2022 - Springer
We used cryopreserved human hepatocytes that express rapid, intermediate, and slow
acetylator N-acetyltransferase 2 (NAT2) genotypes to measure the N-acetylation of β …
acetylator N-acetyltransferase 2 (NAT2) genotypes to measure the N-acetylation of β …
The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic …
DW Hein, RA Salazar-González, MA Doll, Y Zang - Archives of Toxicology, 2023 - Springer
Abstract Human N-acetyltransferase 2 (NAT2) is subject to genetic polymorphism in human
populations. In addition to the reference NAT2* 4 allele, two genetic variant alleles (NAT2 …
populations. In addition to the reference NAT2* 4 allele, two genetic variant alleles (NAT2 …
[HTML][HTML] Acetyl coenzyme A kinetic studies on N-acetylation of environmental carcinogens by human N-acetyltransferase 1 and its NAT1*14B variant
N-acetyltransferase 1 (NAT1) is a xenobiotic metabolizing enzyme that uses acetyl
coenzyme A (AcCoA) as a cofactor for N-acetylation of many carcinogens including aromatic …
coenzyme A (AcCoA) as a cofactor for N-acetylation of many carcinogens including aromatic …
Investigation of human n-acetyltransferases (NAT1 and NAT2) genetic polymorphisms in susceptibility to aromatic amine and alkylaniline genotoxicity.
MRZ Habil - 2022 - ir.library.louisville.edu
Arylamine N-acetyltransferases, NAT1 and NAT2, catalyze the detoxification and/or
activation of carcinogens. Single nucleotide polymorphisms or SNPs result in different …
activation of carcinogens. Single nucleotide polymorphisms or SNPs result in different …