Signaling network regulating osteogenesis in mesenchymal stem cells

S Thomas, BG Jaganathan - Journal of cell communication and signaling, 2022 - Springer
Osteogenesis is an important developmental event that results in bone formation. Bone
forming cells or osteoblasts develop from mesenchymal stem cells (MSCs) through a highly …

Dental pulp stem cell heterogeneity: finding superior quality “needles” in a dental pulpal “haystack” for regenerative medicine‐based applications

ZY Kok, NYA Alaidaroos, A Alraies… - Stem Cells …, 2022 - Wiley Online Library
Human dental pulp stem/stromal cells (hDPSCs) derived from the permanent secondary
dentition are recognised to possess certain advantageous traits, which support their …

Hyaluronic acid hydrogel with adjustable stiffness for mesenchymal stem cell 3D culture via related molecular mechanisms to maintain stemness and induce cartilage …

Y Ren, H Zhang, Y Wang, B Du, J Yang… - ACS Applied Bio …, 2021 - ACS Publications
The stemness and differentiation characteristics of bone marrow mesenchymal stem cells
(BMSCs) in three-dimensional (3D) culture are of great significance for stem cell therapy and …

[HTML][HTML] Effect of cell culture density on dental pulp-derived mesenchymal stem cells with reference to osteogenic differentiation

S Noda, N Kawashima, M Yamamoto, K Hashimoto… - Scientific Reports, 2019 - nature.com
Dental pulp stem cells (DPSCs) are a good source for tissue regeneration, however, the
number of DPSCs in the pulp tissue is limited. Cell propagation is essential for tissue …

Randomised placebo-controlled multicentre trial to evaluate the efficacy and safety of JTR-161, allogeneic human dental pulp stem cells, in patients with Acute …

S Suda, C Nito, M Ihara, Y Iguchi, T Urabe… - BMJ open, 2022 - bmjopen.bmj.com
Introduction JTR-161 is a novel allogeneic human cell product consisting of dental pulp stem
cells isolated from the extracted teeth of healthy adults. It is currently under development as …

[HTML][HTML] Therapeutic potential of dental pulp stem cells and their derivatives: Insights from basic research toward clinical applications

SM Yuan, XT Yang, SY Zhang, WD Tian… - World Journal of Stem …, 2022 - ncbi.nlm.nih.gov
For more than 20 years, researchers have isolated and identified postnatal dental pulp stem
cells (DPSCs) from different teeth, including natal teeth, exfoliated deciduous teeth, healthy …

A critical review of in vitro research methodologies used to study mineralization in human dental pulp cell cultures

S Arora, PR Cooper, JT Ratnayake… - International …, 2022 - Wiley Online Library
Background The pulp contains a resident population of stem cells which can be stimulated
to differentiate in order to repair the tooth by generating a mineralized extracellular matrix …

[HTML][HTML] 3D organoids for regenerative endodontics

FC Li, A Kishen - Biomolecules, 2023 - mdpi.com
Apical periodontitis is the inflammation and destruction of periradicular tissues, mediated by
microbial factors originating from the infected pulp space. This bacteria-mediated …

[HTML][HTML] DPSCs treated by TGF-β1 regulate angiogenic sprouting of three-dimensionally co-cultured HUVECs and DPSCs through VEGF-Ang-Tie2 signaling

Y Zhang, J Liu, T Zou, Y Qi, B Yi… - Stem cell research & …, 2021 - Springer
Background Maintaining the stability and maturation of blood vessels is of paramount
importance for the vessels to carry out their physiological function. Smooth muscle cells …

Epigenetic regulation of dental pulp stem cell fate

D Zhou, L Gan, Y Peng, Y Zhou, X Zhou… - Stem Cells …, 2020 - Wiley Online Library
Epigenetic regulation, mainly involving DNA methylation, histone modification, and
noncoding RNAs, affects gene expression without modifying the primary DNA sequence and …