Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …

Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the
enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has …

Abstract Changes in glycosylation during tumour progression are a key hallmark of cancer.
One of the glycan moieties generally overexpressed in cancer are sialic acids, which can …

Although altered glycosylation has been detected in human cancer cells decades ago, only
investigations in the last years have enormously increased our knowledge about the details …

Pancreatic ductal adenocarcinoma (PDA) is one of the deadliest cancers and is projected to
soon be the second leading cause of cancer death. Median survival of PDA patients is 6–10 …

Simple Summary Sialylation is a post-translational modification that consists in the addition
of sialic acid to growing glycan chains on glycoproteins and glycolipids. Aberrant sialylation …

Cell surface glycosylation is dynamic and often changes in response to cellular
differentiation under physiological or pathophysiological conditions. Altered glycosylation on …

The early detection of pancreatic ductal adenocarcinoma (PDAC) is a complex clinical
obstacle yet is key to improving the overall likelihood of patient survival. Current and …

Pancreatic adenocarcinoma is a lethal disease with a 5‑year survival rate of< 5%, the lowest
of all types of cancer. The diagnosis of pancreatic cancer relies on imaging and tissue …

Metastasis accounts for the majority of cancer-associated mortalities, representing a huge
health and economic burden. One of the mechanisms that enables metastasis is …