Simple Summary This review provides an overview of the state of knowledge and general
understanding of CDK inhibitors currently under development or clinically approved, with a …

Head and neck cancer (HNC) is a term collectively used to describe a heterogeneous group
of tumors that arise in the oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx …

Glioblastoma multiforme (GBM) is the most lethal primary brain tumor with a poor median
survival of less than 15 months. However, clinical strategies and effective therapies are …

Inhibiting Cyclin-dependent kinase 2 (CDK2) has been established as a therapeutic strategy
for the treatment of many cancers. Accordingly, this study aimed at developing a new set of …

ABSTRACT Sirtuin-3 (SIRT3) has been described as a colorectal cancer oncogene and to
be regulated by glycyrrhizic acid (GA). However, few studies have explored the interaction …

With the application of high throughput sequencing technologies at single-cell resolution,
studies of the tumor microenvironment in glioblastoma, one of the most aggressive and …

Metabolic rewiring is a characteristic hallmark of cancer cells. This phenomenon sustains
uncontrolled proliferation and resistance to apoptosis by increasing nutrients and energy …

Abstract Cyclin-dependent kinase 2 (CDK2) is a vital protein for controlling cell cycle
progression that is critically associated with various malignancies and its inhibition could …

Head and neck squamous cell carcinoma (HNSCC) accounts for over 10,000 deaths in the
United States annually. Approximately 80% of HNSCC are human papillomavirus (HPV) …

A series of 12 compounds was designed and synthesized, based on 2-
mercaptobenzoxazole derivatives containing either the substituted benzenes 4a–d …