Glutathione transferases and cancer

S Tsuchida, K Sato - Critical reviews in biochemistry and molecular …, 1992 - Taylor & Francis
The glutathione transferases, a family of multifunctional proteins, catalyze the glutathione
conjugation reaction with electrophilic compounds biotransformed from xenobiotics …

The stem cells of the liver—a selective review

K Aterman - Journal of cancer research and clinical oncology, 1992 - Springer
The current status of the much-debated question of the still-hypothetical stem cells of the
liver is reviewed, with an emphasis on their role in hepatocarcino-genesis. The widely held …

Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments

Y Sakakima, A Hayakawa, T Nagasaka, A Nakao - Journal of hepatology, 2007 - Elsevier
BACKGROUND/AIMS: We examined whether phosphatidylcholine inhibited growth of
hepatic cancer, as previously shown for menaquinone-4 (vitamin K2). METHODS: Growth …

Effects of griseofulvin in medium‐term liver carcinogenesis assay and peripheral blood micronucleus test in rat

K Labay, M Ould‐Elhkim, V Klés… - Teratogenesis …, 2001 - Wiley Online Library
Published data have suggested a possible link between the tumor promoting activity and the
aneugenic properties of griseofulvin. The present study was conducted to explore this …

the stages of gastrointestinal carcinogenesis–application of rodent models to human disease

HC Pitot, H Hikita, Y Dragan… - … & Therapeutics: GERD …, 2000 - Wiley Online Library
The development of gastrointestinal cancer in humans and animals occurs through a
consecutive series of stages termed initiation, promotion and progression. The …

Combined supplementation of vanadium and 1α, 25-dihydroxyvitamin D3 inhibit placental glutathione S-transferase positive foci in rat liver carcinogenesis

R Basak, M Chatterjee - Life Sciences, 2000 - Elsevier
The combined effects of vanadium (V) and 1α, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3] in
inhibiting diethylnitrosamine (DEN)-induced and phenobarbital (PB) promoted …

The same γ‐glutamyl transpeptidase RNA species is expressed in fetal liver, hepatic carcinomas, and rasT24‐transformed rat liver epithelial cells

GM Habib, S Rajagopalan, AK Godwin… - Molecular …, 1992 - Wiley Online Library
In rats,‐γ‐glutamyl transpeptidase (γGT) exists as a single‐copy gene, and three distinct
species of RNA (types I, II, and III) that differ in their 5′ untranslated regions have been …

[HTML][HTML] Type VI RNA is the major gamma-glutamyl transpeptidase RNA in the mouse small intestine.

BZ Carter, GM Habib, AR Sepulveda, R Barrios… - Journal of Biological …, 1994 - Elsevier
Mouse gamma-glutamyl transpeptidase (gamma GT) is encoded by a single copy gene with
at least five and probably six different promoters directing the transcription of six types of …

Glutathione S-transferases and P-glycoprotein in normal rat hepatocytes and hepatoma cells: analysis using flow cytometry

R Mehta, HG Davis, GW Laver, PR Rowsell, GS Bondy - Cancer letters, 1994 - Elsevier
Using indirect immunofluorescence with fluorescein isothiocyanate-conjugated antibodies,
in combination with flow cytometry (FCM), we have developed a technique to detect the α, μ …

Characterization of γ‐glutamyltranspeptidase in the liver of the frog: 2. Response to season, temperature and thyroid hormone in Rana pipiens

SJ Sulakhe‐Hemmings, H Xing - Cell Biochemistry and …, 1994 - Wiley Online Library
The impact of season and temperature on frog liver γ‐glutamyltranspeptidase was assessed
by measuring the activity of this enzyme in plasma membranes isolated from the livers of …