Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …

Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-
related problems assessed with a questionnaire, is a leading cause of death and morbidity …

Neonatal abstinence syndrome (NAS) is a constellation of signs of withdrawal occurring
after birth following in utero exposure to licit or illicit opioids. Despite significant research and …

Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world.
Genetic factors influence smoking behaviours and although strides have been made using …

Abstract Background and Aims Genome‐wide association studies (GWAS) of opioid use
disorder (OUD) and cannabis use disorder (CUD) have lagged behind those of alcohol use …

Substance use disorders represent a significant public health concern with considerable
socioeconomic implications worldwide. Twin and family-based studies have long …

Abstract Background and Aims Genetic risk can influence disease progression. We
measured the impact of genetic risk for substance use disorders (SUDs) on substance use …

Adverse childhood events (ACEs) contribute to the development of mood and anxiety
disorders and substance dependence. However, the extent to which these effects are direct …

Individuals suffering from chronic pain develop substance use disorders (SUDs) more often
than others. Understanding the shared genetic influences underlying the comorbidity …

The integration of multi‐omics information (eg, epigenetics and transcriptomics) can be
useful for interpreting findings from genome‐wide association studies (GWAS). It has been …