The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of
several unmet medical needs, including acute lung injury/acute respiratory distress …

Severe Acute Respiratory Syndrome Coronavirus—2 (SARS CoV-2) has resulted in the
global spread of Coronavirus Disease 2019 (COVID-19) and an increase in complications …

Advancements in methods, technology, and our understanding of the pathobiology of lung
injury have created the need to update the definition of experimental acute lung injury (ALI) …

Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome.
Understanding of the complex pathways involved in lung injury pathogenesis, resolution …

Background Two acute respiratory distress syndrome (ARDS) subphenotypes
(hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and …

BACKGROUND Whether airspace biomarkers add value to plasma biomarkers in studying
acute respiratory distress syndrome (ARDS) is not well understood. Mesenchymal stromal …

Background Acute lung injury (ALI) has received considerable attention in the field of
intensive care as it is associated with a high mortality rate. Obacunone (OB), widely found in …

Rationale: There are limited therapeutic options for patients with coronavirus disease
(COVID-19)-related acute respiratory distress syndrome with inflammation-mediated lung …

Background: Corticosteroids are part of the treatment guidelines for COVID-19 and have
been shown to improve mortality. However, the impact corticosteroids have on the …

Metabolic reprogramming has been shown to aggravate sepsis-induced acute lung injury. In
particular, enhanced glycolysis is closely associated with inflammation and oxidative stress …