Lung ultrasound assessment of focal and non-focal lung morphology in patients with acute respiratory distress syndrome

C Pierrakos, MR Smit, L Pisani, F Paulus… - Frontiers in …, 2021 - frontiersin.org
Background: The identification of phenotypes based on lung morphology can be helpful to
better target mechanical ventilation of individual patients with acute respiratory distress …

Mangiferin mitigates lipopolysaccharide-induced lung injury by inhibiting NLRP3 inflammasome activation

N Li, R Xiong, R He, B Liu, B Wang… - Journal of Inflammation …, 2021 - Taylor & Francis
Scope Mangiferin (MF) is a natural phytopolyphenol, which displays potential
pharmacological properties involving antibacterial, anti-inflammation, antioxidant and anti …

Integrative omics provide biological and clinical insights into acute respiratory distress syndrome

M Du, JGN Garcia, JD Christie, J Xin, G Cai… - Intensive care …, 2021 - Springer
Purpose Acute respiratory distress syndrome (ARDS) is accompanied by a dysfunctional
immune-inflammatory response following lung injury, including during coronavirus disease …

[HTML][HTML] Electrical impedance tomography as a tool for monitoring mechanical ventilation. An introduction to the technique

D Maciejewski, Z Putowski, M Czok… - Advances in Medical …, 2021 - Elsevier
Electrical impedance tomography (EIT) is a non-invasive, radiation-free method of
diagnostics imaging, allowing for a bedside, real-time dynamic assessment of lung function …

Mesenchymal stromal cells-derived extracellular vesicles reprogramme macrophages in ARDS models through the miR-181a-5p-PTEN-pSTAT5-SOCS1 axis

Y Su, JD Silva, D Doherty, DA Simpson, DJ Weiss… - Thorax, 2023 - thorax.bmj.com
Rationale A better understanding of the mechanism of action of mesenchymal stromal cells
(MSCs) and their extracellular vesicles (EVs) is needed to support their use as novel …

The inflammatory lung microenvironment; a key mediator in MSC licensing

H Dunbar, DJ Weiss, S Rolandsson Enes, JG Laffey… - Cells, 2021 - mdpi.com
Recent clinical trials of mesenchymal stromal cell (MSC) therapy for various inflammatory
conditions have highlighted the significant benefit to patients who respond to MSC …

ACT001 suppressing M1 polarization against inflammation via NF-κB and STAT1 signaling pathways alleviates acute lung injury in mice

H Guo, Y Song, F Li, Y Fan, Y Li, C Zhang… - International …, 2022 - Elsevier
ACT001 has been shown to exhibit excellent antitumor and anti-fibrosis activities. However,
the role of ACT001 in acute lung injury (ALI) and the underlying mechanism remains largely …

Identification of acute respiratory distress syndrome subphenotypes de novo using routine clinical data: a retrospective analysis of ARDS clinical trials

A Duggal, R Kast, E Van Ark, L Bulgarelli, MT Siuba… - BMJ open, 2022 - bmjopen.bmj.com
Objectives The acute respiratory distress syndrome (ARDS) is a heterogeneous condition,
and identification of subphenotypes may help in better risk stratification. Our study objective …

Sacubitril/valsartan alleviates sepsis‐induced acute lung injury via inhibiting GSDMD‐dependent macrophage pyroptosis in mice

J Wang, J Li, A Lou, Y Lin, Q Xu, W Cui… - The FEBS …, 2023 - Wiley Online Library
Sepsis‐induced acute lung injury (ALI) is a life‐threatening disorder with intricate
pathogenesis. Macrophage pyroptosis reportedly plays a vital role in ALI. Although it has …

Longitudinal phenotypes in patients with acute respiratory distress syndrome: a multi-database study

H Chen, Q Yu, J Xie, S Liu, C Pan, L Liu, Y Huang… - Critical Care, 2022 - Springer
Background Previously identified phenotypes of acute respiratory distress syndrome (ARDS)
have been limited by a disregard for temporal dynamics. We aimed to identify longitudinal …