Pathobiology of cognitive impairment in Parkinson disease: challenges and outlooks

KA Jellinger - International Journal of Molecular Sciences, 2023 - mdpi.com
Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD)
that poses a severe burden on the patients and caregivers, yet relatively little is known about …

Cholinergic changes in Lewy body disease: Implications for presentation, progression and subtypes

N Okkels, MJ Grothe, JP Taylor, SG Hasselbalch… - Brain, 2024 - academic.oup.com
Cholinergic degeneration is significant in Lewy body disease, including Parkinson's
disease, dementia with Lewy bodies, and isolated REM sleep behaviour disorder. Extensive …

Associations of cholinergic system integrity with cognitive decline in GBA1 and LRRK2 mutation carriers

J Schumacher, N Ray, S Teipel, A Storch - npj Parkinson's Disease, 2024 - nature.com
In Parkinson's disease (PD), GBA1-and LRRK2-mutations are associated with different
clinical phenotypes which might be related to differential involvement of the cholinergic …

Radionuclide Imaging of the neuroanatomical and neurochemical substrate of Cognitive decline in Parkinson's Disease

S Booth, JH Ko - Nuclear Medicine and Molecular Imaging, 2024 - Springer
Cognitive impairment is a frequent manifestation of Parkinson's disease (PD), resulting in
decrease in patients' quality of life and increased societal and economic burden. However …

Cholinergic and noradrenergic aspects of Parkinson's disease

M Husain - Brain, 2024 - academic.oup.com
While neuropathological studies have long made it abundantly clear that Parkinson's
disease extends beyond degeneration of dopaminergic neurons, it has not been until …

Anticholinergic Medication Burden and Cognitive Subtypes in Parkinson's Disease without Dementia

LG Santos, LE Kenney, A Ray… - Archives of Clinical …, 2024 - academic.oup.com
Objective Cognitive changes are heterogeneous in Parkinson's disease (PD). This study
compared whether anticholinergic burden drives differences in cognitive domain …

Mild cognitive impairment in Parkinson's disease: current view

KA Jellinger - Frontiers in Cognition, 2024 - frontiersin.org
Parkinson's disease (PD), the most common motor movement disorder and second most
common neurodegenerative disorder after Alzheimer's disease (AD), is often preceded by a …

Limitations in effective treatment of Parkinson's Disease: neuroanatomical substrate of L-Dopa induced dyskinesia and cognitive impairment

S Booth - 2024 - mspace.lib.umanitoba.ca
Parkinson's disease (PD) is the fastest growing neurodegenerative disease, and in an
increasingly aged population the care and management of PD is an increasing global …