Pharmacotherapies for treatment-resistant depression: how antipsychotics fit in the rapidly evolving therapeutic landscape
One in three adults with major depressive disorder (MDD) do not experience clinically
significant improvement after multiple sequential courses of antidepressants and have …
significant improvement after multiple sequential courses of antidepressants and have …
[HTML][HTML] Neural correlates of co-occurring pain and depression: an activation-likelihood estimation (ALE) meta-analysis and systematic review
CJ Zheng, S Van Drunen… - Translational Psychiatry, 2022 - nature.com
The relationship between pain and depression is thought to be bidirectional and the
underlying neurobiology 'shared'between the two conditions. However, these claims are …
underlying neurobiology 'shared'between the two conditions. However, these claims are …
Acute inflammatory response via neutrophil activation protects against the development of chronic pain
M Parisien, LV Lima, C Dagostino… - Science translational …, 2022 - science.org
The transition from acute to chronic pain is critically important but not well understood. Here,
we investigated the pathophysiological mechanisms underlying the transition from acute to …
we investigated the pathophysiological mechanisms underlying the transition from acute to …
[HTML][HTML] Impact of CYP2C19 metaboliser status on SSRI response: a retrospective study of 9500 participants of the Australian Genetics of Depression Study
Background Variation within the CYP2C19 gene has been linked to differential metabolism
of selective serotonin reuptake inhibitors (SSRIs). Pharmacogenetic recommendations …
of selective serotonin reuptake inhibitors (SSRIs). Pharmacogenetic recommendations …
Insula→ Amygdala and Insula→ Thalamus Pathways Are Involved in Comorbid Chronic Pain and Depression-Like Behavior in Mice
J Chen, Y Gao, ST Bao, YD Wang, T Jia… - Journal of …, 2024 - Soc Neuroscience
The comorbidity of chronic pain and depression poses tremendous challenges for the
treatment of either one because they exacerbate each other with unknown mechanisms. As …
treatment of either one because they exacerbate each other with unknown mechanisms. As …
[HTML][HTML] Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity …
J Zhao, W Shi, Y Lu, X Gao, A Wang, S Zhang, Y Du… - BMC psychiatry, 2022 - Springer
Background Pain and depression often occur simultaneously, but the mechanism of this
condition is still unclear. Methods The aim of this study was to examine the alterations of …
condition is still unclear. Methods The aim of this study was to examine the alterations of …
Neuropathic Pain, Mood, and Stress-Related Disorders: A Literature Review of Comorbidity and Co-Pathogenesis
WF Vieira, DRA Coelho, ST Litwiler… - Neuroscience & …, 2024 - Elsevier
Neuropathic pain can be caused by multiple factors, and its prevalence can reach 10% of
the global population. It is becoming increasingly evident that limited or short-lasting …
the global population. It is becoming increasingly evident that limited or short-lasting …
[HTML][HTML] A shared genetic signature for common chronic pain conditions and its impact on biopsychosocial traits
The multiple comorbidities & dimensions of chronic pain present a formidable challenge in
disentangling its aetiology. Here, we performed genome-wide association studies of 8 …
disentangling its aetiology. Here, we performed genome-wide association studies of 8 …
Pinocembrin inhibits P2X4 receptor–mediated pyroptosis in hippocampus to alleviate the behaviours of chronic pain and depression comorbidity in rats
R Yang, J Yang, Z Li, R Su, L Zou, L Li, X Xu, G Li… - Molecular …, 2022 - Springer
Neuroinflammation is critical to the comorbidity of chronic pain and depression. Pyroptosis is
an inflammatory cell death that is different from apoptosis. Activation of the P2X4 receptor …
an inflammatory cell death that is different from apoptosis. Activation of the P2X4 receptor …
Genetic basis to structural grey matter associations with chronic pain
Structural neuroimaging studies of individuals with chronic pain conditions have often
observed decreased regional grey matter at a phenotypic level. However, it is not known if …
observed decreased regional grey matter at a phenotypic level. However, it is not known if …