One in three adults with major depressive disorder (MDD) do not experience clinically
significant improvement after multiple sequential courses of antidepressants and have …

The relationship between pain and depression is thought to be bidirectional and the
underlying neurobiology 'shared'between the two conditions. However, these claims are …

The transition from acute to chronic pain is critically important but not well understood. Here,
we investigated the pathophysiological mechanisms underlying the transition from acute to …

Background Variation within the CYP2C19 gene has been linked to differential metabolism
of selective serotonin reuptake inhibitors (SSRIs). Pharmacogenetic recommendations …

The comorbidity of chronic pain and depression poses tremendous challenges for the
treatment of either one because they exacerbate each other with unknown mechanisms. As …

Background Pain and depression often occur simultaneously, but the mechanism of this
condition is still unclear. Methods The aim of this study was to examine the alterations of …

Neuropathic pain can be caused by multiple factors, and its prevalence can reach 10% of
the global population. It is becoming increasingly evident that limited or short-lasting …

The multiple comorbidities & dimensions of chronic pain present a formidable challenge in
disentangling its aetiology. Here, we performed genome-wide association studies of 8 …

Neuroinflammation is critical to the comorbidity of chronic pain and depression. Pyroptosis is
an inflammatory cell death that is different from apoptosis. Activation of the P2X4 receptor …

Structural neuroimaging studies of individuals with chronic pain conditions have often
observed decreased regional grey matter at a phenotypic level. However, it is not known if …