Expansion of the coding and regulatory capabilities of eukaryotic transcriptomes by
alternative splicing represents one of the evolutionary forces underlying the increased …

Most human genes undergo alternative splicing (AS), and dysregulation of alternative
splicing contributes to tumor initiation and progression. Computational analysis of genomic …

Alternative splicing is an important source of heterogeneity underlying gene expression
between individual cells but remains an understudied area due to the paucity of …

Abstract Protein arginine methyltransferase 9 (PRMT9) is a recently identified member of the
PRMT family, yet its biological function remains largely unknown. Here, by characterizing an …

Five-prime single-cell RNA-seq (scRNA-seq) has been widely employed to profile cellular
transcriptomes, however, its power of analysing transcription start sites (TSS) has not been …

Abnormal gene alternative splicing (AS) events are strongly associated with cancer
progression. Here, we summarize AS events that contribute to the development of drug …

We present VALERIE (Visualising alternative splicing events from single-cell ribonucleic
acid-sequencing experiments), an R package for visualising alternative splicing events at …

Alternative splicing, a ubiquitous phenomenon in eukaryotes, is a regulatory mechanism for
the biological diversity of individual genes. Most studies have focused on the effects of …

Abdominal aortic aneurysm (AAA) is a common and serious disease with a high mortality
rate, but its genetic determinants have not been fully identified. In this feasibility study, we …

Alternative splicing (AS) is a key transcriptional regulation pathway. Recent studies have
shown that AS events are associated with the occurrence of complex diseases. Various …