Medicinal chemistry perspective of JAK inhibitors: synthesis, biological profile, selectivity, and structure activity relationship
JAK-STAT signalling pathway was discovered more than quarter century ago. The JAK-
STAT pathway protein is considered as one of the crucial hubs for cytokine secretion which …
STAT pathway protein is considered as one of the crucial hubs for cytokine secretion which …
In silico screening of a series of 1,6-disubstituted 1H-pyrazolo[3,4-d]pyrimidines as potential selective inhibitors of the Janus kinase 3
Rheumatoid arthritis is a common chronic disabling inflammatory disease that is
characterized by inflammation of the synovial membrane and leads to discomfort. In the …
characterized by inflammation of the synovial membrane and leads to discomfort. In the …
QSAR-driven screening uncovers and designs novel pyrimidine-4, 6-diamine derivatives as potent JAK3 inhibitors
This study presents a robust and integrated methodology that harnesses a range of
computational techniques to facilitate the design and prediction of new inhibitors targeting …
computational techniques to facilitate the design and prediction of new inhibitors targeting …