Emerging roles for LXRs and LRH-1 in female reproduction

K Mouzat, S Baron, G Marceau, F Caira, V Sapin… - Molecular and cellular …, 2013 - Elsevier
Nutritional status is known to control female reproductive physiology. Many reproductive
pathologies such as anorexia nervosa, dystocia and preeclampsia, have been linked to …

Intestine-specific regulation of PPARα gene transcription by liver X receptors

S Colin, E Bourguignon, AB Boullay, JJ Tousaint… - …, 2008 - academic.oup.com
Liver X receptor-α (LXRα) and LXRβ are ligand-activated transcription factors belonging to
the nuclear receptor superfamily. They have been identified as key players in cholesterol …

Activation of nuclear receptor NR5A2 increases Glut4 expression and glucose metabolism in muscle cells

A Bolado-Carrancio, JA Riancho, J Sainz… - Biochemical and …, 2014 - Elsevier
NR5A2 is a nuclear receptor which regulates the expression of genes involved in
cholesterol metabolism, pluripotency maintenance and cell differentiation. It has been …

Expression of the Pregnane X Receptor in Mice Antagonizes the Cholic Acid–Mediated Changes in Plasma Lipoprotein Profile

D Masson, L Lagrost, A Athias, P Gambert… - … , and vascular biology, 2005 - Am Heart Assoc
Objective—Modification of lipoprotein metabolism by bile acids has been mainly explained
by activation of the farnesyl X receptor (FXR). The aim of the present study was to determine …

[HTML][HTML] Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2)

S Busby, P Nuhant, M Cameron… - Probe Reports from …, 2011 - ncbi.nlm.nih.gov
NR5A2 (Liver receptor homologue-1; LRH1) belongs to the four-member NR5A, or Ftz-F1,
subfamily V of nuclear receptors. Murine LRH1 was originally identified due to its sequence …

PPARγ Represses Apolipoprotein A‐I Gene but Impedes TNFα‐Mediated ApoA‐I Downregulation in HepG2 Cells

VS Shavva, DA Mogilenko… - Journal of cellular …, 2016 - Wiley Online Library
ABSTRACT Apolipoprotein A‐I (ApoA‐I) is the main anti‐atherogenic component of human
high‐density lipoproteins (HDL). ApoA‐I gene expression is regulated by several nuclear …

Pioglitazone increases apolipoprotein AI production by directly enhancing PPRE-dependent transcription in HepG2 cells

LH Zhang, VS Kamanna, SH Ganji, XM Xiong… - Journal of lipid …, 2010 - ASBMB
Pioglitazone, a hypoglycemic agent, has been shown to increase plasma HDL cholesterol,
but the mechanism is incompletely understood. We further investigated effects of …

LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish

G Zhai, J Song, T Shu, J Yan, X Jin, J He… - Journal of genetics and …, 2017 - Elsevier
Abstract Liver receptor homolog-1 (LRH-1) is an orphan nuclear receptor that is critical for
the growth and proliferation of cancer cells and other biological processes, including lipid …

α1-Fetoprotein transcription factor (FTF)/liver receptor homolog-1 (LRH-1) is an essential lipogenic regulator

Z Xu, L Ouyang, A del Castillo-Olivares… - … et Biophysica Acta (BBA …, 2010 - Elsevier
α1-Fetoprotein transcription factor (FTF), also known as liver receptor homolog 1 (LRH-1) is
highly expressed in the liver and intestine, where it is implicated in the regulation of …

Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its …

A Shimada, H Kimura, K Oida, H Kanehara… - Lipids in Health and …, 2016 - Springer
Background Statins decrease cholesteryl ester transfer protein (CETP) levels, which have
been positively associated with hepatic lipid content as well as serum low density …