RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

Much of the human proteome is involved in mRNA homeostasis, but most RNA-binding
proteins lack chemical probes. Here we identify electrophilic small molecules that rapidly …

Background A critical step in uncovering rules of RNA processing is to study the in vivo
regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation …

Nuclear proteins are often given a concise title that captures their function, such as
'transcription factor,''polymerase'or 'nuclear-receptor.'However, for members of the …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

In many cells, mRNAs containing inverted repeats (Alu repeats in humans) in their 3′
untranslated regions (3′ UTRs) are inefficiently exported to the cytoplasm. Nuclear …

The C-terminal repeat domain (CTD), an unusual extension appended to the C terminus of
the largest subunit of RNA polymerase II, serves as a flexible binding scaffold for numerous …

Long noncoding RNAs (lncRNA) participate in carcinogenesis and tumor progression in
lung cancer. Here, we report the identification of a lncRNA signature associated with …

Transcription in the nucleus occurs in a concentrated, dense environment, and no
reasonable biochemical facsimile of this milieu exists. Such a biochemical environment …